Science

May 3, 2025, 11:14

Myeloma Paper of the Day, May 3rd, suggested by Robert Orlowski

Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:

“Myeloma Paper of the Day: Study of outcomes in frail patients getting bispecifics finds best ORR 80% in frail vs 73% in non-frail group; no significant difference in median PFS (NR vs 11 mos) or OS (37 vs 25 mos); similar rates of all grade CRS and ICANS.”

Title: Outcomes in Frail Patients Receiving BCMA-directed Bispecific Antibodies for Relapsed/Refractory Multiple Myeloma

Authors: Benjamin O Adegbite, Carlyn Rose Tan, Tala Shekarkhand, Ross S Firestone, Eric Matthew Jurgens, Kevin C. Miller, Alexander M Lesokhin, Gunjan L Shah, Neha Korde, Sridevi Rajeeve, Heather J Landau, Michael Scordo, Hani Hassoun, Kylee H. Maclachlan, Urvi A Shah, Malin L Hultcrantz, Issam S. Hamadeh, Andriy Derkach, David Nemirovsky, Sergio A. Giralt, Sham Mailankody, Saad Z Usmani, Hamza Hashmi.

You can read the Full Article on Blood Advances.

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Myeloma Paper of the Day, May 3rd, suggested by Robert Orlowski

“Myeloma Paper of the Day: Study of outcomes in frail patients getting bispecifics finds best ORR 80% in frail vs 73% in non-frail group; no significant difference in median PFS (NR vs 11 mos) or OS (37 vs 25 mos); similar rates of all grade CRS and ICANS.”