Angela Mastronuzzi: Circulating microRNAs as non-invasive biomarkers from adult to pediatric brain tumor patients
Angela Mastronuzzi, Pediatric Hematologist-oncologist and the Head of Neuro-Oncology Unit at Bambino Gesù Children’s Hospital, shared an article she and her colleagues authored on LinkedIn:
“”Circulating microRNAs: A remarkable opportunity as non-invasive biomarkers from adult to pediatric brain tumor patients” – published with Critical Reviews in Oncology/Hematology.
Highlights:
• Prevalence and Impact: CNS tumors are the most common solid tumors in pediatric age and the top cause of cancer-related death in adults.
• Diagnostic Challenges: Current protocols (MRI, histology, molecular characterization, and CSF cytology) require invasive procedures with limited accuracy.
• Need for Non-Invasive Biomarkers: Identifying reliable non-invasive biomarkers can improve diagnosis, stratification and follow-up.
• Role of MicroRNAs (miRNAs): miRNAs, dysregulated in brain tumor patients, are measurable in liquid biopsies.
• Review Aim: This review examines circulating miRNAs in liquid biopsy as potential cancer biomarkers for adults and children and explores their potential impact on clinical trials.”
Authors: Federica D’Antonio et al.
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