Angela Mastronuzzi: MicroRNAs Expression Profile in MN1-Altered Astroblastoma
Angela Mastronuzzi, President of AIOEP, shared a post on LinkedIn about a recent paper she co-authored with colleagues published in Biomedicines:
” ‘MicroRNAs Expression Profile in MN1-Altered Astroblastoma’ just published with BioMedicines of MDPI.
We investigated microRNA expression, regulation, and biological processes correlated to target genes of deregulated miRNAs in MN1-altered astroblastoma.
Methods: A cohort of 14 tumor samples, histologically classified as astroblastoma, was retrospectively collected and analyzed through their DNA methylation profiles.
Conclusions: MN1-altered astroblastomas have an miRNA expression signature that identifies specific BPs and pathways. Our findings suggested that the involved pathways could be associated with clinical and pathological characteristics of MN1-altered astroblastomas. Also, the biology of this raretumor could have potential implications on prognostic markers and therapy.
Special thank you to The Italian Association for the fight against Neuroblastoma that funded this research.”
“MicroRNAs Expression Profile in MN1-Altered Astroblastoma”
Authors: Francesca Gianno, Evelina Miele, Claudia Sabato, Angela Mastronuzzi, Antonio d’Amati, Giuseppina Catanzaro et al.
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