Wafik El-Deiry, former Associate Dean for Oncologic Sciences and Founding Director of the Cancer Center at Brown University, shared most recommended papers on X.
“Lactate takes a shortcut into mitochondria to power the heart
A cellular fuel called lactate is channelled directly into energy-generating organelles in heart muscle, defying the prevailing view about lactate transport.
Authors: Trace Thome, Zolt Arany
Genetic variants that alter gene regulation in specific cell types are closely tied to disease
Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and health.
Authors: Heini M. Natri, Nicholas E. Banovich
Insights into early-onset colorectal cancer from a single-nucleus RNA-seq atlas of colorectal cancer across the age continuum
Authors: Caroline B. M. Porter, Shane P. Murphy, Jules Cazaubiel, Toni M. Delorey, Liat Amir-Zilberstein, Orr Ashenberg, Liubou Klindziuk, Elizabeth Andrews, William Tan, Kosuke Matsuda, Atsushi Kondo, Satoko Ugai, Tomotaka Ugai, Shuji Ogino, Emily Finan, Jacques Deguine, Ewa Sicinska, Lauren K. Brais, Jennifer S. Thalappillil, Marios Giannakis, Ramnik J. Xavier, Ana C. Anderson, Kimmie Ng
Methylated eEF1A selectively decodes mRNA to shape cancer proteomes
Authors: Shuo Liu, F. Aaron Cruz-Navarrete, Simone Hausmann, Krzysztof J. Szkop, Sabeen Ikram, Ryan A. Brady, Xiaoyin Lu, Rui Dong, Julia Vu, Natasha M. Flores, Emily Zahn, Julia Thompson, Ben A. Garcia, Ola Larsson, Ivan Topisirovic, Scott C. Blanchard, Or Gozani, Pawel K. Mazur
Perforin triggers iron-induced mitochondrial damage to drive ferroptosis and anti-tumor immunity
Authors: Hannah N. Bell, Kavya Nair, Kole Tison, Peng Liao, Hongwei Lei, Marwa O. El-Derany, Ayijiang Yisimayi, Haiwei Zhang, Ryan Rebernick, Weichao Wang, Yoshitaka Adachi, Cristina Castillo, Nupur K. Das, Jinsu An, Vivien R. Sutton, Xun Lin, Heng Lin, Xinghao Wang, Yunfei Li, Linda Vatan, Amr Aboud, Shuang Wei, Miguel Gijon, Samantha Goodwin, Yatrik M. Shah, Ilona Kryczek, Joseph A. Trapani, Margarida Barroso, Judy Lieberman, Weiping Zou
p53 activation via pharmacologic MDM2 inhibition constrains exhaustion and enhances antitumor function of human CD8+ T cells
Authors: Alexandra Boix de Jesus, Hy B. Dao, Anthony Imani, Gabriel A. Rodriguez, Michael S. Shehata, Rachana R. Chandran, Stuart A. Fine, Sin Y. Lim, Michelle To, Serena Y. Lofftus, Nicolas Pedroncelli, Fritz C. Eilber, Brigitte N. Gomperts, Tyler R. McCaw, Cristina Puig-Saus, Joseph G. Crompton
AMG-232 sensitizes high MDM2-expressing tumor cells to T-cell-mediated killing
Authors: Ilyas Sahin, Shengliang Zhang, Arunasalam Navaraj, Lanlan Zhou, Don Dizon, Howard Safran, Wafik El-Deiry
Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic cancer: the randomized phase 2 AMPLIFY-7P trial
Authors: Ben George, Harshabad Singh, Craig E. Devoe, Vincent Chung, Peter J. Hosein, Andrew Hendifar, Dae Won Kim, Jennifer B. Valerin, Tanios Bekaii-Saab, Dana B. Cardin, Manuel Hidalgo, Pashtoon M. Kasi, Alexis D. Leal, Meredith Pelster, Naomi Fei, Colin D. Weekes, Mark H. O’Hara, Thomas J. George, Syed M. Kazmi, Jonathan D. Mizrahi, Suresh Nair, Martin Maiers, Thian Kheoh, Gianni Amato, Jino Xavier, Julia P. Snyder, Madison H. Milaszewski, Xavier Cabana-Puig, James R. Perry, Lisa K. McNeil, Esther Welkowsky, Peter C. DeMuth, Christopher M. Haqq, Shubham Pant, Zev A. Wainberg, Eileen M. O’Reilly
Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers
Authors: Eliza Yankova, Alexandra Sapetschnig, Beth Thomas, Siân Evans, Maria Eleftheriou, Malgorzata Gozdecka, Harry Fischl, Teresa Brevini, Rachael Wilson, Sarah J. Bucknell, Andrew Hutchin, Carmen M. Livi, George Giotopoulos, Ryan Asby, Laura Bond, Aleksandra Azevedo, Natalie Webster, Jack Rogan, James Russell, Byron Andrews, Hendrik Weisser, Joanna Baxter, Judith López-Luis, Giovanna Mantica, Jake Tobin, Diego Lopez-Leon, Dean C. Pask, Vidur Tandon, Richard Fosbeary, Sapphire Sawyer, Sunay Usluer, Nithila Joseph, Evangelia Stamou, Maria T. Bejar, Yogeshkumar Malam, Roland Rad, Elisa Laurenti, Juan Li, Maria P. Alcolea, David J. Adams, Walid T. Khaled, Fotios Sampaziotis, George S. Vassiliou, Brian J. P. Huntly, Oliver Rausch, Konstantinos Tzelepis
SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin
Authors: Sonia Debek, Cem Meydan, Christopher R. Chin, Jiali Yu, Ceyda Durmaz, Ioanna Tsialta, Benedikt Pelzer, Constance Maurer, Arnold Ou, Alejandra Laguillo-Diego, Laurianne Scourzic, Sravya Tumuluru, Matt Teater, Rui Wu, Brian Darsow, Martin A. Rivas, Jose Luis Marin-Rubio, Matthias Stadtfeld, Effie Apostolou, Christopher E. Mason, Kojo S. J. Elenitoba-Johnson, Viviana I. Risca, Ari Melnick, Darko Barisic
Tumour assembloids recapitulate tumour–CAF–T cell crosstalk in renal cancer
Authors: Eunjee Kim, Minyong Kang, Jang Hee Han, Juhee Lee, Yunhee Kim, Chang Wook Jeong, HyeSun Lee, Hyun Je Kim, Kunyoo Shin
Tumor digital twins uncover therapeutic strategies in triple-negative breast cancer
Authors: Pedro Victori, Kui Hua, Alecia-Jane Twigger, Akanksha Anand, Zera M. Bose, Matthew A. Clarke, Steven Bell, Katrina J.Q. Xian, Lama Zakarneh, Karen Pinilla, Colin Y.C. Lee, Menna R. Clatworthy, Walid T. Khaled, Jean E. Abraham, PARTNER Trial Group, Personalised Breast Cancer Program Group, Gregory J. Hannon, Jasmin Fisher
Next-generation AI for visually occult pancreatic cancer detection in a low-prevalence setting with longitudinal stability and multi-institutional generalisability
Authors: Sovanlal Mukherjee, Ajith Antony, Nandakumar G Patnam, Kamaxi H Trivedi, Aashna Karbhari, Khurram Khaliq Bhinder, Armin Zarrintan, Joel G Fletcher, Mark Truty, Matthew P Johnson, Suresh T Chari, Ajit Harishkumar Goenka
Harnessing endogenous carbon monoxide for cancer-selective drug synthesis
Authors: Masayuki Kawai, Tsung-Che Chang, Ambara R. Pradipta, Katsunori Tanaka
Other articles from Wafik El-Deiry on OncoDaily.