Breast Cancer Research Digest by Dana-Farber’s Breast Oncology Center
Dana-Farber’s Breast Oncology Center shared a post on X:
“Check out the newest Breast Cancer Research Digest – a summary of last week’s publications from select high-impact journals (June 1st-6th, 2025).”
Title: Randomized trial of a community-based, culturally tailored intervention: High engagement among Latina breast cancer survivors.
Authors: Katarina E. AuBuchon, Claudia J. Campos Galván, Ysabel Duron BA, Ivis Sampayo, Migdalia Torres LCSW-R, Alejandra Hurtado-de-Mendoza, Charlene Kuo, Christina Rush, Maria Gloria Elliott LPC, Jennie Santiago, Olympia Cepeda, Laura A. Logie, Astrid Jimenez, George Luta, Kristi D. Graves
Title: Tebotelimab plus niraparib in previously treated locally advanced or metastatic solid tumors: A phase 1b dose escalation and expansion study.
Authors: Miao-Zhen Qiu, Hongming Pan, Ka On Lam, Jufeng Wang, Yi Zheng, Huiping Li, Xinhong Wu, Li Wang, Lequn Bao, Jing Cheng, Yanxia Shi, Yunong Gao, Min Yan, Huiyan Luo, Yu Zheng, Xiaoa Zhen, Wenzhao Hang, Jianmei Hou, Rui-Hua Xu
Title: Causal Effects of Breast Cancer Risk Factors across Hormone Receptor Breast Cancer Subtypes: A Two-Sample Mendelian Randomization Study.
Authors: Renée M G Verdiesen, Mehrnoosh Shokouhi, Stephen Burgess, Sander Canisius, Jenny Chang-Claude, Stig E Bojesen, Marjanka K Schmidt
Title: Peri-operative atezolizumab in early-stage triple-negative breast cancer: final results and ctDNA analyses from the randomized phase 3 IMpassion031 trial.
Authors: Elizabeth A. Mittendorf, Zoe June Assaf, Nadia Harbeck, Hong Zhang, Shigehira Saji, Kyung Hae Jung, Roberto Hegg, Andreas Koehler, Joohyuk Sohn, Hiroji Iwata, Melinda L. Telli, Cristiano Ferrario, Kevin Punie, Aditi Qamra, Max Dieterich, Yun Xu, Mario Liste-Hermoso, Esther Shearer-Kang, Luciana Molinero, Stephen Y. Chui, Carlos H. Barrios
Title: Atezolizumab plus paclitaxel and bevacizumab as first-line treatment of advanced triple-negative breast cancer: the ATRACTIB phase 2 trial.
Authors: María Gion, Isabel Blancas, Patricia Cortez-Castedo, Alfonso Cortés-Salgado, Frederik Marmé, Salvador Blanch, Serafín Morales, Nieves Díaz, Isabel Calvo-Plaza, Sabela Recalde, Alejandro Martínez-Bueno, Manuel Ruiz-Borrego, Elisenda Llabrés, María Teresa Taberner, Michelino de Laurentiis, Silvia García-Vicente, José Antonio Guerrero, Olga Boix, Jose Rodríguez-Morató, Miguel Sampayo-Cordero, Gabriele Antonarelli, José Manuel Pérez-García, Javier Cortés, Antonio Llombart-Cussac
Title: Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy.
Authors: Eleftherios P. Mamounas, Hanna Bandos, Julia R. White, Thomas B. Julian, Atif J. Khan, M.D., Simona F. Shaitelman, Mylin A. Torres, Frank A. Vicini, Patricia A. Ganz, Susan A. McCloskey, Peter C. Lucas, Nilendu Gupta, X. Allen Li, Beryl McCormick, Benjamin Smith, Rahul D. Tendulkar, Vivek S. Kavadi, Koji Matsumoto, Samantha Andrews Seaward, William J. Irvin, Jr., Jolinta Y. Lin, Robert W. Mutter, Thierry M. Muanza, Jannifer Stromberg, Reshma Jagsi, Anna C. Weiss, Walter J. Curran, Jr., and Norman Wolmark,
Title: Breast imaging recommendations for young females (age < 40 years) with ≥ 20% lifetime breast cancer risk: practice patterns at a specialized clinic.
Authors: Alexandra Wehbe, Fisher Katlin, Eshita Sharma, Marybeth Hans, Mary Knust Graichen, Brittany L Bychkovsky, Rochelle Scheib, Judy E Garber, Lydia E Pace, Tari A King, Alison Laws
Title: Multimodality Treatment De-Intensification in Node-Negative, Hormone-Receptor Breast Cancer: What Are the Limits?
Authors: Naamit Kurshan Gerber, Jenni Yeong-shin Sheng, Alastair Thompson, Jean Wright
Title: Twenty-five years without progress: The enduring challenge of soft tissue sarcomas.
Authors: Nicole J. Hardy, Khaoula Ben Haj Frej, Rachel Nkansah, Kelly Olino, Hari Deshpande, Xiaomei Ma, Jonathan C. Trent, Philippos Costa
Title: Implications of omitting sentinel lymph node biopsy on adjuvant decision making for patients with small breast cancers.
Authors: Kerollos Nashat Wanis, Melissa P Mitchell, Sharon H Giordano, Jennifer Keating Litton, Simona F Shaitelman, Nina Tamirisa, Isabelle Bedrosian, Wenli Dong, Yu Shen, Kelly K Hunt, Puneet Singh, Susie X Sun, Abigail S Caudle, Henry M Kuerer, Funda Meric-Bernstam, Rosa F Hwang, Taiwo Adesoye
Title: First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer.
Authors: François-Clément Bidard, Erica L Mayer, Yeon Hee Park, Wolfgang Janni, Cynthia Ma, Massimo Cristofanilli, Giampaolo Bianchini, Kevin Kalinsky, Hiroji Iwata, Stephen Chia, Peter A Fasching, Adam Brufsky, Zbigniew Nowecki, Javier Pascual, Lionel Moreau, Shin-Cheh Chen, Nuri Karadurmus, Einav Nili Gal-Yam, Kyung Hae Jung, Sonia Pernas, Sasha McClain, Wei He, Teresa Klinowska, Cynthia Huang-Bartlett, Nicholas C Turner
Title: The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression.
Authors: Jayashree Thatte, Ana Moisés da Silva, Judit Börcsök, Thorkell Gudjónsson, Jan Benada, Xin Li, Muthiah Bose, Hanneke van der Gulden, Ji-Ying Song, Renée Menezes, Elena Martín-Doncel, Luis Toledo, Valdemaras Petrosius, Cord Brakebusch, Jos Jonkers, Finn Cilius Nielsen, Maria Rossing, Claus S Sørensen
Title: Divergent combinations of enhancers encode spatial gene expression.
Authors: Danni Hong, Muya Shu, Jiamao Liu, Lifang Liu, Hao Cheng, Ming Zhu, Yi Du, Bo Xu, Di Hu, Zhiyong Liu, Yannan Zhao, Jianwu Dai, Falong Lu, Jialiang Huang
Title: KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.
Authors: Zheqi Li, Guillermo Peluffo, Laura E. Stevens, Xintao Qiu, Marco Seehawer, Amatullah Tawawalla, Xiao-Yun Huang, Shawn B. Egri, Shaunak Raval, Maeve McFadden, Clive S. D’Santos, Eva Papachristou, Natalie L. Kingston, Jun Nishida, Kyle E. Evans, Ji-Heui Seo, Kendell Clement, Daniel Temko, Muhammad Ekram, Rong Li, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Anton Simeonov, Stephen C. Kales, Ganesha Rai, Madhu Lal-Nag, David J. Maloney, Ajit Jadhav, Franziska Michor, Alex Meissner, Justin M. Balko, Jason S. Carroll, Matthew L. Freedman, Jacob D. Jaffe, Malvina Papanastasiou, Henry W. Long, Kornelia Polyak
Title: Low Socioeconomic Status at the Patient and Institutional Level Impact Achievement of Breast Cancer Quality Standards.
Authors: Kristen M. HoSang, Richard J. Bleicher, Katharine A. Yao, Jill R. Dietz, Austin D. Williams
Title: Elinzanetant for Vasomotor Symptoms from Endocrine Therapy for Breast Cancer.
Authors: Fatima Cardoso, Susanne Parke, Donal J. Brennan, Paula Briggs, Gilbert Donders, Nick Panay, Nazanin Haseli-Mashhadi, Michael Block, Cecilia Caetano, Maja Francuski, Claudia Haberland, Kaisa Laapas, Christian Seitz, Lineke Zuurman,
Title: Genetic inactivation of FAAP100 causes Fanconi anemia due to disruption of the monoubiquitin ligase core complex.
Authors: Julia Kuehl, Yutong Xue, Fenghua Yuan, Ramanagouda Ramanagoudr-Bhojappa, Simone Pickel, Reinhard Kalb, Settara C Chandrasekharappa, Weidong Wang, Yanbin Zhang, Detlev Schindler
Title: Advances in CTC and ctDNA detection techniques: opportunities for improving breast cancer care.
Authors: Hai-Jing Zhong, Yumiao Zhen, Shiji Chen, Wei Shi, Xiaoxu Liang, Guan-Jun Yang
Title: Logistic and time burdens reported by gynecologic and breast cancer survivors.
Authors: Allison C. Dona, Aisha Ambo, Patricia Jewett, Katherine Brown, Helen Parsons, Arjun Gupta, Deanna Teoh, Anne Blaes, Rachel I. Vogel
Title: Clinicopathological features and genomics of ER-positive/HER2- negative breast cancer relapsing on adjuvant abemaciclib.
Authors: C Corti, A R Martin, P T Kurnia, J Gómez Tejeda Zañudo, D L Abravanel, M E Hughes, T Parker, P Tarantino, G Curigliano, T A King, E A Mittendorf, N U Lin, S M Tolaney
Title: Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer.
Authors: Aviad Ben-Shmuel, Yael Gruper, Coral Halperin, Oshrat Levi-Galibov, Hallel Rosenberg-Fogler, Debra Barki, Giulia Carradori, Yaniv Stein, Gal Yagel, Mariia Naumova, Shimrit Mayer, Maya Dadiani, Dana Morzaev-Sulzbach, Ofra Golani, Reinat Nevo, Ziv Porat, Einav Nili Gal-Yam, Ruth Scherz-Shouval
Title: Clinical Validity of Repeated Circulating Tumor Cell Enumeration as an Early Treatment Monitoring Tool for Metastatic Breast Cancer in the PREDICT Global Pooled Analysis.
Authors: Wolfgang Janni, Thomas W.P. Friedl, Tracy C. Yab, Francois-Clément Bidard, Massimo Cristofanilli, Daniel F. Hayes, Michail Ignatiadis, Meredith M. Regan, Catherine Alix-Panabieres, William E. Barlow, Carlos Caldas, Lisa A. Carey, Luc Dirix, Tanja Fehm, Jose A. Garcia-Saenz, Paola Gazzaniga, Daniele Generali, Lorenzo Gerratana, Rafael Gisbert-Criado, William Jacot, Zefei Jiang, Simon A. Joosse, Evi Lianidou, Rafael López López, Mark J.M. Magbanua, Luis Manso, Dimitris Mavroudis, Volkmar Müller, Elisabetta Munzone, Klaus Pantel, Jean-Yves Pierga, Brigitte Rack, Sabine Riethdorf, Hope S. Rugo, Kostandinos Sideras, Stefan Sleijfer, Jeffrey Smerage, Justin Stebbing, Leon W.M.M. Terstappen, Jose Vidal-Martínez, Markus Wallwiener, Karthik V. Giridhar, Minetta C. Liu
Title: Historical Redlining and All-Cause Survival after Breast Cancer Diagnosis.
Authors: Sarah M. Lima, Tia M. Palermo, Furrina F. Lee, Tabassum Z. Insaf, Helen C.S. Meier, Lili Tian, Henry Louis Taylor, Jr, Deborah O. Erwin, Heather M. Ochs-Balcom
Title: Racialized Economic Segregation, Treatment, and Outcomes in Women with Triple-Negative Breast Cancer.
Authors: Stanton Davis, Min Lian, Graham A Colditz, Kia L Davis, James Struthers, Ying Liu
Title: Detection of Circulating Tumor DNA Using a Tissue-Free Epigenomic Assay Is a Highly Prognostic Biomarker in Early- Stage Triple-Negative Breast Cancer.
Authors: Foluso O Ademuyiwa, Cynthia X Ma, Katherine Weilbaecher, Rama Suresh, Lindsay L Peterson, Ron Bose, Nusayba Bagegni, Caron E Rigden, Ashley Frith, Katherine Clifton, Derek Dustin, Mingyang Cai, Liyang Xiong, Sai Chen, Andrew A Davis
Title: p16, COX-2, and Ki67 Protein Expression in DCIS and Risk of Ipsilateral Invasive Breast Cancer.
Authors: Thomas E. Rohan, Chenxin Zhang, Yihong Wang, Fergus J. Couch, Robert T. Greenlee, Stacey Honda, Azadeh Stark, Larissa L. White, Dhananjay A. Chitale, Xiaonan Xue, Mindy Ginsberg, Olivier Loudig
Title: Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study.
Authors: Bethany T. Ogbenna, Xin He, Anna H. Wu, Loïc Le Marchand, Lynne R. Wilkens, James Butler, Typhanye Dyer, Iona Cheng, Cher M. Dallal
Title: Human Immunodeficiency Virus-Associated Differences in the Tumor Immune Microenvironment of Lung, Breast, and Prostate Cancers.
Authors: Jordan Fenlon, Nathan Van Bibber, Jonathon Mahlow, Kosj Yamoah, Alex C Soupir, Jonathan V Nguyen, Carlos Moran Segura, Adam M Spivak, Beatrice S Knudsen, Qin Zhou, Siwen Hu-Lieskovan, Sonam Puri, Wei Zhang, Yoko S DeRose, Gita Suneja, Anna E Coghill
Title: Reproducibility of Plasma Metabolome over 1 Year in a Population-Based Cohort of Black Breast Cancer Survivors.
Authors: Bo Qin, Madhir Vyas, Steven C. Moore, Xiaoyang Su, Eileen P. White, Coral Omene, Tengteng Wang, Mi-Hyeon Jang, Kitaw Demissie, Chi-Chen Hong, Elisa V. Bandera
Title: The Breast Tumor Immune Microenvironment of DNA Double- Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages.
Authors: Rebecca L. Kelly, Yuxi Liu, Alexandra R. Harris, Cheng Peng, Yujing J. Heng, Gabrielle M. Baker, Daniel G. Stover, Rulla M. Tamimi, Peter Kraft
Title: Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy.
Authors: Eleftherios P. Mamounas, Hanna Bandos, Julia R. White, Thomas B. Julian, Atif J. Khan, Simona F. Shaitelman, Mylin A. Torres, Frank A. Vicini, Patricia A. Ganz, Susan A. McCloskey, Peter C. Lucas, Nilendu Gupta, X. Allen Li, Beryl McCormick, Benjamin Smith, Rahul D. Tendulkar, Vivek S. Kavadi, Koji Matsumoto, Samantha Andrews Seaward, William J. Irvin, Jr., Jolinta Y. Lin, Robert W. Mutter, Thierry M. Muanza, Jannifer Stromberg, Reshma Jagsi, Anna C. Weiss, Walter J. Curran, Jr., Norman Wolmark
Title: Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing.
Authors: Peikai Ding, Shengbin Pei, Yi Zhai, Zheng Qu, Yazhe Yang, Xiaolong Feng, Qiang Liu, Xiangyu Wang, Wenxiang Zhang, Zhongzhao Wang, Xiangyi Kong, Jing Wang, Yi Fang
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