American Cancer Society Journals shared a post on LinkedIn:
“Just published in CA: A Cancer Journal for Clinicians. Advanced Urologic Cancer Consensus Conference (AUC3) 2025: Expert consensus on the management of renal cell and urinary tract cancers.
The therapeutic landscape for renal cell carcinoma (RCC) and urinary tract cancer (UTC) has transformed dramatically, creating complexity in treatment selection and sequencing.
The 2025 Advanced Urologic Cancer Consensus Conference was convened to establish evidence-based expert consensus recommendations for optimal management. A multidisciplinary panel of 51 experts participated in a modified Delphi process addressing questions developed through iterative consensus-building covering RCC and UTC management.
There was strong consensus on the use of enfortumab vedotin plus pembrolizumab as frontline therapy for metastatic UTC and the use of platinum-based chemotherapy postprogression in biomarker-negative UTC.
For RCC, there was consensus on the role of single-agent vascular endothelial growth factor receptor–tyrosine kinase inhibitor therapy after progression on frontline immune checkpoint inhibitor/vascular endothelial growth factor receptor–tyrosine kinase inhibitor therapy or dual immune checkpoint inhibitor therapy.
Title: Advanced Urologic Cancer Consensus Conference (AUC3) 2025: Expert consensus on the management of renal cell and urinary tract cancers
Full author list: Rana McKay MD, Sumanta Pal, MD, FASCO, Wanling Xie MS, David Aggen M.D., Ph.D., Laurence Albiges MD, PhD, Andrea Apolo MD, Michael B. Atkins MD, Rick Bangs MBA, PMP, Kathryn Beckermann MD, PhD, Joaquim Bellmunt MD, PhD, Stephanie Berg DO, Mehmet Bilen MD, David Braun MD, PhD, Maria Carlo MD, Jason Efstathiou MD, DPhil, Matthew Galsky MD, Petros Grivas MD, PhD, Shilpa Gupta, MD MD, Naomi Haas MD, A. Ari Hakimi MD, Hans Hammers MD, PhD, Daniel Y. C. Heng MSC, Michelle Hirsch MD, PhD, Gopakumar Iyer MD, Eric Jonasch MD, Vadim Koshkin MD, Oleksandr Kryvenko MD, Bryan Lewis JD, Roger Li MD, Surena Matin MD, Benjamin Maughan MD, PharmD, David F. McDermott MD, Bradley McGregor MD, Joshua Meeks MD, PhD, Matthew Milowsky MD, Robert Motzer MD, Andrea Necchi MD, Daniel Petrylak MD, Sima Porten MD, MPH, Tom Powles MBBS, MRCP, MD, Brian Rini MD, Brian Shuch MD, Arlene Siefker-Radtke MD, Guru Sonpavde, MD, S. Srikala Sridhar MD, Cristina Suarez MD, PhD, Chad Tang MD, Abhishek Tripathi MD, Michiel S. Van Der Heijden MD, PhD, Martin Voss MD, Wenxin Xu MD, Tian Zhang MD, Jonathan Rosenberg MD, Toni Choueiri MD.
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