Robert Olson, Professor, Division Head of Radiation Oncology at The University of British Columbia, shared a post on LinkedIn about a paper he co-authored with colleagues published in BMC Cancer:
“Following yesterday’s milestone with COMET-3 accrual completion, our focus now shifts to our SIMPLIFY RCT comparing single vs multiple fraction SABR.
SIMPLIFY evaluates whether toxicity from a single large fraction is non-inferior to toxicity from multiple smaller fractions in patients with oligomets or oligoprogression (1-5 sites).
This question is especially relevant for rural, remote, and Indigenous communities, since single fraction treatment allows patients to leave their home communities for a shorter time. SIMPLIFY also incorporates decentralized follow up options, which allow participants to complete much of their follow up from home.
Today, Jordanna Laing and Hadassah Abraham are helping me coordinate a Site Initiation Visit for Princess Margaret Cancer Centre, with site PI Chiaojung Jillian Tsai. While the rural and remote impact is clear, participation from large centres is equally important, as it strengthens generalizability to urban settings, improves implementation potential, and contributes substantial accrual that benefits the entire trial.
The trial is already accruing quickly across nine of thirty planned centres, with approximately eleven more expected to activate over the coming year across Scotland, Ontario, Quebec, and Ireland. This next wave of sites will significantly expand access and capacity as we move into 2026.”
Title: Single vs. multiple fraction non-inferiority trial of stereotactic ablative radiotherapy for the comprehensive treatment of oligo-metastases/progression: SIMPLIFY-SABR-COMET
Authors: Robert Olson, Hadassah Abraham, Curtis Leclerc, Alexander Benny, Sarah Baker, Quinn Matthews, Nick Chng, Alanah Bergman, Benjamin Mou, Emma M. Dunne, Devin Schellenberg, Will Jiang, Elisa Chan, Siavash Atrchian, Shilo Lefresne, Hannah Carolan, Boris Valev, Scott Tyldesley, Andrew Bang, Tanya Berrang, Haley Clark, Fred Hsu, Alexander V. Louie, Andrew Warner, David A. Palma, Doris Howell, Aisling Barry, Laura Dawson, Petra Grendarova, Debra Walker, Rishi Sinha, Jillian Tsai, Houda Bahig, Isabelle Thibault, Rashmi Koul, Sashendra Senthi, Iain Phillips, Derek Grose, Paul Kelly, John Armstrong, Ronan McDermott, Candice Johnstone, Srini Vasan, Noel Aherne, Stephen Harrow, Mitchell Liu
You can read the full article in BMC Cancer.
