Mina L. Xu, Physician, Professor of Pathology at Yale University School of Medicine, Director of Hematopathology, shared Rong Fan’s, Harold Hodgkinson Professor of Biomedical Engineering and Pathology at Yale University, post on X, adding:
“So happy to share this newly published study looking at the spatial genomic and epigenetic transformation of follicular lymphoma. Huge thank you Rong Fan, Haikuo Li and the entire Fan lab for making this dream possible!”
Quoting Rong Fan’s post:
“Excited to see this in print! Kudos to Haikuo, Bo, and the entire team including Mina L. Xu, Yale Pathology, Jingtian Zhou, Arc Institute to explore this clinically relevant area of lymphoma transformation with truly innovative technology.
Epi-Patho-DBiT is a spatial multiomics platform that enables in situ profiling of epigenetic states from routinely archived FFPE tissues: combining DBiT with ATAC-seq and CUTandTag to spatially resolve chromatin accessibility and histone modifications within biopsies.
It uncovered how different lymphoma cell populations evolve within the same tumor, including copy-number alterations, and cholesterol mediated proliferations. We also traced the transformation of follicular lymphoma into aggressive DLBCL at the genomic and epigenetic level.
A striking discovery in transformed follicular lymphoma: region in chromosome 2 showed both high expression of cancer-promoting genes and high expression of repressive mark H3K27me3, showing how genome alterations and epigenetic regulation interact during cancer progression.”
Title: Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT
Authors: Haikuo Li, Bo Tao, Archibald Enninful, Dingyao Zhang, Yi Dai, Fiona Oh, Negin Farzad, Keyi Li, Zhiliang Bai, Xiaoyu Qin, Mingyu Yang, Emily J. Hwang, Jing Zhang, Jun Lu, Mark Gerstein, Jingtian Zhou, Mina L. Xu, Rong Fan
Other articles featuring Mina L. Xu and Rong Fan on OncoDaily.