Michael Sturdivant, PhD Candidate at University of North Carolina at Chapel Hill, shared a post on LinkedIn, about a recent article he and his colleagues co-authored, adding:
“Excited to share that my first co–first author paper has been published in Nature Portfolio’s Nature Communications ‘APOBEC3 promotes squamous differentiation via IL-1A/AP-1 signaling’. In this study, we identify APOBEC3A as being associated with squamous differentiation in urothelial carcinoma.
We generated a murine bladder cancer model with conditional knockout of PTEN and TP53, coupled with overexpression of Apobec3, to assess the role APOBEC3 plays in bladder cancer progression.
We show that AP-1 transcription factors are required for APOBEC3-induced squamous differentiation, mediated through activation of IL-1R1 signaling.
Single-cell RNA sequencing and spatial transcriptomic analyses of human bladder cancer tumors reveal that APOBEC3A expression is confined to epithelial cell populations with high squamous activity.
Targeting Apobec3-induced lineage plasticity and urothelial to squamous transdifferentiation may offer a novel strategy to prevent therapeutic resistance.
Special thank you to my co-first author Andrew Truong and my PI William Y. Kim!!!”
Title: APOBEC3 promotes squamous differentiation via IL-1A/AP-1 signaling
Authors: Michael S. Sturdivant, Andrew S. Truong, Mi Zhou, Elliott D. Toomer, Wolfgang Beckabir, John Raupp, Ujjawal Manocha, Ibardo A. Zambrano, Hung-Jui Tan, Marc A. Bjurlin, Angela B. Smith, Tracy L. Rose, Matthew I. Milowsky, Sara E. Wobker, Kathryn H. Gessner, Jeffrey S. Damrauer, William Y. Kim
Read the Full Article on Nature Communications
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