Lung Cancer Europe shared a post on LinkedIn:
“Brain metastases remain one of the major challenges in lung cancer care.
Around 20-40% of people with lung cancer develop brain metastases during the course of their disease.
Treating tumors in the brain is particularly difficult because many therapies struggle to cross the blood-brain barrier.
New research published in Nature Biomedical Engineering explores whether engineered immune cells could help overcome this barrier and attack tumors in the brain.
The study describes specially designed macrophages that were able to cross into the brain and suppress metastases in laboratory models.
While this work is still at an early stage, it highlights the range of new approaches researchers are exploring to improve the treatment of brain metastases.”
Title: MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis
Authors: Shih-Ying Wu, Abhishek Tyagi, Kerui Wu, Eleanor C. Smith, Qianqian Song, Sambad Sharma, Lance D. Miller, Wei Zhang, Bo-Syong Pan, Hui-Kuan Lin, Jung-Shun Lee, Ashok Pullikuth, Fei Xing, Ravindra Pramod Deshpande, Dan Zhao, Yin Liu, Jee Won Kim, Michael H. Soike, Jimmy Ruiz, Michael Chan, Jeff Chou, Alexandra Parson, Kounosuke Watabe
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