Federico Pio Fabrizio, Associate Professor in Molecular Biology at Kore University of Enna, shared an article he co-authored with colleagues, published in Cancer Letters:
“Response to neoadjuvant chemoimmunotherapy in resectable NSCLC remains highly heterogeneous, highlighting the role of the tumor microenvironment (TME) in therapeutic outcomes. Tumor-associated macrophages (TAMs) are associated with immunosuppression, T-cell dysfunction, and reduced response to PD-1/PD-L1–based therapies.
Evidence from breast cancer and emerging data in NSCLC suggest that TAM enrichment correlates with lower pathological complete response rates. Importantly, their predictive value depends not only on abundance but also on spatial distribution and interaction with immune and stromal components. Spatial transcriptomics enables high-resolution mapping of TAM phenotypes within the TME, revealing mechanisms of immune evasion and resistance, including cytokine-mediated suppression and interference with checkpoint blockade.
In our editorial, we propose that integrating spatial and functional profiling of TAMs may improve patient stratification and support the development of macrophage-targeted therapeutic strategies.”
Title: Can Macrophages Predict Response to Neoadjuvant Therapy in Lung Cancer? A Lesson from Breast Cancer
Authors: Federico Pio Fabrizio, Francesco Pegreffi, Rosario Leonardi, Massimiliano Mazza, Sara Bravaccini
Read the Full Article.
You can read more articles featuring Federico Pio Fabrizio on OncoDaily.