Purdue Institute for Cancer Research shared a post on LinkedIn:
“Cancer’s most dangerous behaviors, including immune evasion, therapy resistance and metastasis, can arise not only from mutations in DNA itself, but also from disruptions in the system that controls gene expression.
Purdue University researcher Emily Dykhuizen studies chromatin regulation, the molecular machinery that determines which genes are accessible in a cell. When chromatin regulators are misregulated, genes that should remain silenced can be switched on, enabling cancer cells to take on new functions and identities.
In a collaboration with fellow Purdue Institute for Cancer Research member Michael Wendt, Dykhuizen is investigating why breast cancer cells lose their ability to metastasize to the lungs when a chromatin remodeling gene is silenced. Researchers suspect the change may restore an immune response that had previously been suppressed.
Read the story to learn more.”
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