Memorial Sloan Kettering Cancer Center(MSKCC) shared a post on X about a recent article by Danny Luan et al, published in Blood:
“New MSK research suggests circadian rhythms may influence how patients respond to CAR T cell therapy for large B cell lymphoma. Patients treated before noon showed higher 1-year progression-free survival.
‘The link between circadian rhythms and treatment effectiveness is a relatively new area of research,’says MSK’s Roni Shouval.
‘By studying this connection, we hope to improve the way CAR T therapy is administered, so that more people can benefit from this potentially lifesaving therapy.’
Title: Time of Day of CAR T-Cell Infusion and Outcomes in Large B-Cell Lymphoma
Authors: Danny Luan, Ori Ben Valid, Ofrat Beyar-Katz, Tobias Tix,Noa Golan-Accav,
Mohammad Alhomoud, Abraham Avigdor,Veit L. Bücklein, Limor Cohen,Parastoo B Dahi, Sigrun Einarsdottir, Julia Elimelech, Silvia Escribano Serrat, Lorenzo Falchi, Teng Fei, Sergio A. Giralt, Marina Gomez-Llobell, Andre Goy, Nurit Horesh, Sapir Israeli, Linus Kruk, Lori A. Leslie, Jennifer K Lue, Ronit Marcus, Arnon Nagler, M. Lia Palomba, Jae H Park, Sandeep S Raj, Siddhartha Thammineni Reddy, Jason T. Romancik, Efrat Rosenbaum, Gilles A. Salles, Michael Scordo, Gunjan L. Shah, Avichai Shimoni,Michael von Bergwelt-Baildon, Miguel-Angel Perales, Marion Subklewe, Uri Greenbaum, Andrew Ip, Ron Ram, Kai Rejeski, Roni Shouval
Read the full article on Blood.
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