Loay Kassem: 11 Pivotal Trials From ASCO 2025 Published in The NEJM
Loay Kassem, Assistant Professor of Clinical Oncology at Kasr AlAiny School of Medicine, shared a post on LinkedIn:
“If you only have 15 minutes to review updates from ASCO 2025, Don’t miss these studies:
The 11 pivotal trials, published in NEJM (and hence considered by many to be practice changing).
I usually start reviewing any new updates by scanning those major studies. If I have more time, I scan all the oral sessions, then mini-oral, etc….
If you have other studies that could change your practice next week, put it in the comments.”
Title: Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy
Authors: Giannis Mountzios, Longhua Sun, Byoung Chul Cho, Umut Demirci, Sofia Baka, Mahmut Gümüş, Antonio Lugini, Bo Zhu, Yan Yu, Ippokratis Korantzis, Ji-Youn Han, Tudor-Eliade Ciuleanu, Myung-Ju Ahn, Pedro Rocha, Julien Mazières, Sally C.M. Lau, Martin Schuler, Fiona Blackhall, Tatsuya Yoshida, Taofeek K. Owonikoko, Luis Paz-Ares, Tony Jiang, Ali Hamidi, Diana Gauto, Gonzalo Recondo, Charles M. Rudin
Title: Elinzanetant for Vasomotor Symptoms from Endocrine Therapy for Breast Cancer
Authors: Fatima Cardoso, Susanne Parke, Donal J. Brennan, Paula Briggs, Gilbert Donders, Nick Panay, Nazanin Haseli-Mashhadi, Michael Block, Cecilia Caetano, Maja Francuski, Claudia Haberland, Kaisa Laapas, Christian Seitz, Lineke Zuurman
Title: Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer
Authors: Patrick M. Forde, Jonathan D. Spicer, Mariano Provencio, Tetsuya Mitsudomi, Mark M. Awad, Changli Wang, Shun Lu, Enriqueta Felip, Scott J. Swanson, Julie R. Brahmer, Keith Kerr, Janis M. Taube, Tudor-Eliade Ciuleanu, Fumihiro Tanaka, Gene B. Saylors, Ke-Neng Chen, Hiroyuki Ito, Moishe Liberman, Claudio Martin, Stephen Broderick, Lily Wang, Junliang Cai, Quyen Duong, Stephanie Meadows-Shropshire, Joseph Fiore, Sumeena Bhatia, Nicolas Girard
Title: First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer
Authors: François-Clément Bidard, Erica L. Mayer, Yeon Hee Park, Wolfgang Janni, Cynthia Ma, Massimo Cristofanilli, Giampaolo Bianchini, Kevin Kalinsky, Hiroji Iwata, Stephen Chia, Peter A. Fasching, Adam Brufsky, Zbigniew Nowecki, Javier Pascual, Lionel Moreau, Shin-Cheh Chen, Nuri Karadurmus, Einav Nili Gal-Yam, Kyung Hae Jung, Sonia Pernas, Sasha McClain, Wei He, Teresa Klinowska, Cynthia Huang-Bartlett, Nicholas C. Turner
Title: Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
Authors: Kerry S. Courneya, Janette L. Vardy, Christopher J. O’Callaghan, Sharlene Gill, Christine M. Friedenreich, Rebecca K.S. Wong, Haryana M. Dhillon, Victoria Coyle, Neil S. Chua, Derek J. Jonker, Philip J. Beale, Kamal Haider, Patricia A. Tang, Tony Bonaventura, Ralph Wong, Howard J. Lim, Matthew E. Burge, Stacey Hubay, Michael Sanatani, Kristin L. Campbell, Fernanda Z. Arthuso, Jane Turner, Ralph M. Meyer, Michael Brundage, Patti O’Brien, Dongsheng Tu, Christopher M. Booth
Title: Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer
Authors: Elena Y. Janjigian, Salah-Eddin Al-Batran, Zev A. Wainberg, Kei Muro, Daniela Molena, Eric Van Cutsem, Woo Jin Hyung, Lucjan Wyrwicz, Do-Youn Oh, Takeshi Omori, Markus Moehler, Marcelo Garrido, Sulene C.S. Oliveira, Moishe Liberman, Victor Castro Oliden, Elizabeth C. Smyth, Alexander Stein, Mehmet Bilici, Maria Lorena Alvarenga, Vadim Kozlov, Fernando Rivera, Akihito Kawazoe, Olivier Serrano, Eric Heilbron, Alejandra Negro, John F. Kurland, Josep Tabernero
Title: Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer
Authors: Kohei Shitara, Eric Van Cutsem, Mahmut Gümüş, Sara Lonardi, Christelle de la Fouchardière, Clélia Coutzac, Jeroen Dekervel, Daniel Hochhauser, Lin Shen, Wasat Mansoor, Bo Liu, Lorenzo Fornaro, Min-Hee Ryu, Jeeyun Lee, Cátia Faustino, Jean-Philippe Metges, Josep Tabernero, Fábio Franke, Yelena Y. Janjigian, Fabricio Souza, Lori Jukofsky, Yumin Zhao, Takahiro Kamio, Aziz Zaanan, Filippo Pietrantonio
Title: Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma
Authors: Danny Rischin, Sandro Porceddu, Fiona Day, Daniel P. Brungs, Hayden Christie, James E. Jackson, Brian N. Stein, Yungpo Bernard Su, Rahul Ladwa, Gerard Adams, Samantha E. Bowyer, Zulfiquer Otty, Naoya Yamazaki, Paolo Bossi, Amarnath Challapalli, Axel Hauschild, Annette M. Lim, Vishal A. Patel, Joanna L. Walker, Maite De Liz Vassen Schurmann, Paola Queirolo, Javier Cañueto, Flavio Augusto Ferreira da Silva, Alexander Stratigos, Alexander Guminski, Charles Lin, Fernanda Damian, Lukas Flatz, Anne E. Taylor, David R. Carr, Samuel Harris, Dmitry Kirtbaya, Gaëlle Quereux, Piotr Rutkowski, Nicole Basset-Seguin, Nikhil I. Khushalani, Caroline Robert, Haisong Ju, Camryn Joseph, Shikha Bansal, Chieh-I Chen, Frank Seebach, Suk-Young Yoo, Israel Lowy, Priscila Goncalves, Matthew G. Fury
Title: Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer
Authors: Mario Campone, Michelino De Laurentiis, Komal Jhaveri, Xichun Hu, Sylvain Ladoire, Anne Patsouris, Claudio Zamagni, Jiuwei Cui, Marina Cazzaniga, Timucin Cil, Katarzyna J. Jerzak, Christian Fuentes, Tetsuhiro Yoshinami, Alvaro Rodriguez-Lescure, Ahmet Sezer, Andrea Fontana, Valentina Guarneri, Andrea Molckovsky, Marie-Ange Mouret-Reynier, Umut Demirci, Yongqiang Zhang, Olga Valota, Dongrui R Lu, Marcella Martignoni, Janaki Parameswaran, Xin Zhi, Erika P. Hamilton
Title: Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer
Authors: Komal L. Jhaveri, Seock-Ah Im, Cristina Saura, Sibylle Loibl, Kevin Kalinsky, Peter Schmid, Sherene Loi, Eirini Thanopoulou, Noopur Shankar, Yanling Jin, Thomas J. Stout, Tiffany D. Clark, Chunyan Song, Dejan Juric, Nicholas C. Turner
Title: Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer
Authors: Elena Elez, Takayuki Yoshino, Lin Shen, Sara Lonardi, Eric Van Cutsem, Cathy Eng, Tae Won Kim, Harpreet Singh Wasan, Jayesh Desai, Fortunato Ciardiello, Rona Yaeger, Timothy S. Maughan, Van K. Morris, Christina Wu, Tiziana Usari, Robert Laliberte, Samuel S. Dychter, Xiaosong Zhang, Josep Tabernero, Scott Kopetz
Read OncoDaily’s Special Articles about ASCO 2025:
Highlights from ASCO 2025 Day 1
Highlights from ASCO 2025 Day 2
Highlights from ASCO 2025 Day 3
Highlights from ASCO 2025 Day 4
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