Highlights from WCLC24 by Stephen V Liu Part 2

The WCLC24 is taking place at the San Diego Convention Center from September 7 to 10, 2024.

Organized by the International Association for the Study of Lung Cancer (IASLC), this major conference is gathering leading experts, researchers, and oncologists to present and discuss the latest advancements in lung cancer research, treatment, and personalized therapies, fostering collaborative efforts towards overcoming the challenges of lung cancer.

Stephen V Liu, Associate Professor of Medicine at Georgetown University, shared some insights from the conference.

Impact of brain metastases on ML-6070 (DLL3 BiTE)

Noura Choudhury impact of brain metastases on ML-6070 (DLL3 BiTE) at WCLC24.

Brain metastases permitted at entry if treated, asymptomatic, and stable for at least 2w. Patients with SRS for isolated CNS metastases did well on therapy.

25% of patients had baseline CBS lesions resolve.

Ticiana Batista discusses the emerging BiTEs for SCLC at WCLC24

Comprehensive development plans being put in place to identify the optimal approach and setting.

BI 764532 (now obrixtamig) in large cell neuroendocrine carcinoma (LCNEC)

Martin Wermke discusses BI 764532 (now obrixtamig) in large cell neuroendocrine carcinoma (LCNEC) at WCLC24.

CRS seen (low grade and early) and dysgeusia. RR 28% at active dose levels.

Maintenance tarlatamab for SCLC

Sally Lau presents phase Ib DeLLphi-303: maintenance tarlatamab for SCLC at WCLC24.

After 4-6 cycles of platinum plus etoposide plus atezolizumab or durvalumab, given tarlatamab 10mg/kg maintenance and immunotherapy.

No new safety signals – low rates of discontinuation from AE.

CRS mostly grade 1-2 and in cycle 1

Median duration of disease control was 9.3m. PFS from maintenance, PFS 5.6m. OS immature.

Luis Paz-Ares receiving the 2024 Heine H. Hansen Lectureship Award

Big congratulations to Luis Paz-Ares, the 2024 Heine H. Hansen Lectureship Award for Small Cell Lung Cancer!

A brilliant investigator, compassionate clinician, gifted speaker, and a friend to us all.

WCLC24 highlights include seeing friends through the meeting

WCLC24 highlights include seeing friends through the meeting – Gerry Hanna, Jonathan Riess, Corey Langer, Chris Draft.

For part one of the WCLC24 highlights by Stephen V Liu, click here