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Myeloma Paper of the Day, June 11th, suggested by Robert Orlowski
Jun 11, 2025, 13:00

Myeloma Paper of the Day, June 11th, suggested by Robert Orlowski

Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:

“Myeloma Paper of the Day: Biallelic antigen escape may be a mechanism of resistance to anti-CD38 antibodies; L153H and C275Y decreased binding affinity and ADCC of daratumumab and isatuximab, while a 3rd, R140G, conferred selective resistance to dara only.”

Title: Biallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma

Authors: Benjamin T. Diamond, Linda B Baughn, Mansour Poorebrahim, Alexandra M Poos, Holly Lee, Marcella Kaddoura, J Erin Wiedmeier-Nutor, Michael A. Durante, Gregory E Otteson, Dragan Jevremovic, Hongwei Tang, Stefan Fröhling, Marc-Andrea Baertsch, Marios Papadimitriou, Bachisio Ziccheddu, Tomas Jelínek, Cendrine Lemoine, Alexey Rak, Damian J Green, Carl Ola Landgren, Paola Neri, Peter Leif Bergsagel, Esteban Braggio, Shaji K Kumar, Marc S. Raab, Rafael Fonseca, Nizar Bahlis, Niels Weinhold, Francesco Maura.

Myeloma Paper of the Day, June 11th, suggested by Robert Orlowski

You can read the Full Article in Blood.

More posts featuring Robert Orlowski.