Moran Amit, Co-Director of the Neuroscience Program at UT MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Assistant Professor at MD Anderson Cancer Center, shared on LinkedIn:
”For many years we excluded them from immunotherapy trials.
Immunosuppressed patients, maybe we just need to think differently about their immunity.
It’s all about macrophages, not T cells (well, T cell diversity)
Massive collaboration with UT MD Anderson, Cleveland Clinic, Moffitt Cancer Center, University of Pennsylvania, reveals that the immune microenvironment of organ transplant recipients is dampened, not absent.
Kunal Rai, Shorook Naara, Kenneth Tsai, Veena Kochat, Jing Wang, Neil Gross, Priyadharsini Nagarajan, Frederico O. Gleber-Netto, thank you!
For working so hard to make this world a better place for patients work immunosuppression.
Check out our paper in Cell by Cell Press.”
Titles: Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer
Authors: Shorook Naara, Veena Kochat, Xiayu Rao, Emre Arslan, Robert Saddawi-Konefka, Suresh Satpati, Jennifer Garbarino, Jennifer L. Anderson, Frederico O. Gleber-Netto, Priyadharsini Nagarajan, Travis D. Kerr, Shamima Akhter, Sophie Li, R’ay Fodor, Shlomo A. Koyfman, Dan Yaniv, Tongxin Xie, Mica Glaun, Michael Bobian, William Israel Padron, Colin Ng, Preethi H. Gunaratne, Shiyanth Thevasagayampillai, Michael R. Migden, Hussein A. Abbas, Patrick K. Reville, Kenneth Y. Tsai, Daniel J. McGrail, Jing Wang, Jeffrey N. Myers, Neil D. Gross, Kunal Rai, Moran Amit.
You can also read: ‘Sequencing After Enfortumab Vedotin and Pembrolizumab in Advanced Urothelial Carcinoma‘
