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Oscar Tahuahua Shares NEJM Study on Nonoperative PD-1 Blockade in dMMR Tumors
May 1, 2025, 14:32

Oscar Tahuahua Shares NEJM Study on Nonoperative PD-1 Blockade in dMMR Tumors

Oscar Tahuahua, Medical Oncology fellow at the National Cancer Institute of Mexico, shared on X about a recent paper by Andrea Cercek et al. published in NEJM:

“Nonoperative Management of Mismatch Repair–Deficient Tumors in NEJM

Ph 2 study, neoadjuvant dostarlimab (PD-1 inh) achieved 82% cCR and 80% organ preservation in stage I–III dMMR tumors, with 92% 2-year RFS; 44% had Lynch syndrome”

Oscar Tahuahua

Authors: Andrea Cercek, Michael B. Foote, Benoit Rousseau, J. Joshua Smith, Jinru Shia, Jenna Sinopoli, Jill Weiss, Melissa Lumish, Lindsay Temple, Miteshkumar Patel, Callahan Wilde, Leonard B. Saltz, Guillem Argiles, Zsofia Stadler, Oliver Artz, Steven Maron, Geoffrey Ku, Ping Gu, Yelena Y. Janjigian, Daniela Molena, Gopa Iyer, Jonathan Coleman, Wassim Abida, Seth Cohen, Kevin Soares, Mark Schattner, Vivian E. Strong, Rona Yaeger, Philip Paty, Marina Shcherba, Ryan Sugarman, Paul B. Romesser, Alice Zervoudakis, Avni Desai, Neil H. Segal, Imane El Dika, Maria Widmar, Iris Wei, Emmanouil Pappou, Gerard Fumo, Santiago Aparo, Mithat Gonen, Marc Gollub, Vetri S. Jayaprakasham, Tae-Hyung Kim, Julio Garcia Aguilar, Martin Weiser, Luis A. Diaz, Jr.

Journal: NEJM – The New England Journal of Medicine

Read full insight here.

Read more about dMMR on OncoDaily:

“Organ Preservation in dMMR Tumors: Results from Neoadjuvant Phase II Study with Dostarlimab”

dMMR solid tumors