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Oscar Tahuahua Shares NEJM Study on Nonoperative PD-1 Blockade in dMMR Tumors
Oscar Tahuahua/X
May 1, 2025, 14:32

Oscar Tahuahua Shares NEJM Study on Nonoperative PD-1 Blockade in dMMR Tumors

Oscar Tahuahua, Medical Oncology fellow at the National Cancer Institute of Mexico, shared on X about a recent paper by Andrea Cercek et al. published in NEJM:

“Nonoperative Management of Mismatch Repair–Deficient Tumors in NEJM

Ph 2 study, neoadjuvant dostarlimab (PD-1 inh) achieved 82% cCR and 80% organ preservation in stage I–III dMMR tumors, with 92% 2-year RFS; 44% had Lynch syndrome”

Oscar Tahuahua

Authors: Andrea Cercek, Michael B. Foote, Benoit Rousseau, J. Joshua Smith, Jinru Shia, Jenna Sinopoli, Jill Weiss, Melissa Lumish, Lindsay Temple, Miteshkumar Patel, Callahan Wilde, Leonard B. Saltz, Guillem Argiles, Zsofia Stadler, Oliver Artz, Steven Maron, Geoffrey Ku, Ping Gu, Yelena Y. Janjigian, Daniela Molena, Gopa Iyer, Jonathan Coleman, Wassim Abida, Seth Cohen, Kevin Soares, Mark Schattner, Vivian E. Strong, Rona Yaeger, Philip Paty, Marina Shcherba, Ryan Sugarman, Paul B. Romesser, Alice Zervoudakis, Avni Desai, Neil H. Segal, Imane El Dika, Maria Widmar, Iris Wei, Emmanouil Pappou, Gerard Fumo, Santiago Aparo, Mithat Gonen, Marc Gollub, Vetri S. Jayaprakasham, Tae-Hyung Kim, Julio Garcia Aguilar, Martin Weiser, Luis A. Diaz, Jr.

Journal: NEJM – The New England Journal of Medicine

Read full insight here.

Read more about dMMR on OncoDaily:

“Organ Preservation in dMMR Tumors: Results from Neoadjuvant Phase II Study with Dostarlimab”

dMMR solid tumors

Alice Zervoudakis Andrea Cercek Avni Desai Benoit Rousseau Callahan Wilde cancer Daniela Molena dMMR tumors Emmanouil Pappou Geoffrey Ku Gerard Fumo Gopa Iyer Guillem Argiles Imane El Dika Iris Wei J. Joshua Smith Jenna Sinopoli Jill Weiss Jinru Shia Jonathan Coleman Jr. Julio Garcia-Aguilar Kevin Soares Leonard B Saltz Lindsay Temple Luis A. Diaz Marc Gollub Maria Widmar Marina Shcherba Mark Schattner Martin Weiser Melissa Lumish Michael B. Foote Miteshkumar Patel Mithat Gönen Neil H. Segal NEJM Oliver Artz OncoDaily Oncology Oscar Tahuahua Paul B. Romesser Philip Paty Ping Gu Rona Yaeger Ryan Sugarman Santiago Aparo Seth Cohen Steven Maron Tae-Hyung Kim Vetri S. Jayaprakasham Vivian E. Strong Wassim Abida Yelena Y. Janjigian Zsofia Stadler
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