Pavlos Msaouel: Just published our review on how to interpret RCTs focusing on key concepts.

Pavlos Msaouel, Assistant Professor of Genitourinary Medical Oncology at MD Anderson Cancer Center, made the following post on LinkedIn:

“Just published our review on how to interpret RCTs focusing on key concepts such as sampling and allocation, uncertainty and variability, relevance and robustness, intention to treat & per protocol, potential outcomes and counterfactuals.

Emphasis is given on how RCTs connect with physical processes to inform inferences and decisions. Frequentist inferences can become more intuitive by converting p-values and confidence intervals/distributions into bits of refutational information via the use of S-values.

We also use selection diagrams to illustrate key RCT concepts and challenges, such as the need to carefully analyze overall survival estimates when evaluating treatment regimes in diseases with available subsequent therapies.

For better visualization of survival curves, we highlight Frank Harrell’s advice and rstats survplot function to plot the comparative survival differences. This allows readers to quickly and easily make more reliable inferences.”

For details click here
Source: Pavlos Msaouel/Twitter