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Foxpaws Fauxpas Shared PACT Study Results on CPLE for Chemo-Induced Thrombocytopenia
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Jun 3, 2025, 15:15

Foxpaws Fauxpas Shared PACT Study Results on CPLE for Chemo-Induced Thrombocytopenia

Foxpaws Fauxpas, Clinical Oncologist, shared a post on X:

“PACT
Chemo-induced thrombocytopenia
– Triple-blinded, RCT Phase III
– N = 219 (2:1 randomization)
– Solid tumor patients- grade 2–3 CIT (Plt <75K, >25K)
Intervention:
– CPLE 1100 mg PO TID
– until Plt>75K, transfusion/D+10
Primary Endpoint: Plt >75K by Day+4
Results (N=198 analyzed)
CPLE: 129
Placebo: 69
Baseline: Balanced except more Grade 3 CIT in placebo (p = 0.049)
Chemo regimens:
• Oxaliplatin: 37%
• Carboplatin: 27%
Plt >75K at D+4
CPLE: 64%
Placebo: 48%
p = 0.034 
Faster recovery with CPLE in:
– 3-weekly V weekly regimens
– Pall > curative
– >2 cycles
– BSA < 1.6
No Gr3–4 AEs with CPLE!
CPLE = 1st to significantly improve CIT
Maintains chemo intensity
Consider as 2° prophylaxis in grade 2–3 CIT!”

PACT

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