Luca Arecco/X
Jun 4, 2025, 08:14
Luca Arecco Presented in Clinical Science Symposium at ASCO25 – New data from CARRIERS study
Luca Arecco, Clinical Research Fellow at ESMO, shared a post on X:
“Presented in Clinical Science Symposium at ASCO25 new data from CARRIERS study
Among >25,000 patients with BC, germline BRCA1 and BRCA2 carriers were linked to worse OS in ER+ BC
No OS impact for ATM, CHEK2, or PALB2 (PALB2 a trend to worse OS)
In >25,000 women, PVs in ATM, BRCA1, BRCA2, CHEK2, or PALB2 were found in 6% Impact on OS was gene- and subtype-specific. For ER+ diseases: BRCA1: HR 1.8 (p=0.02) BRCA2: HR 1.8 (p<0.001)
Significant worse OS compared to non-carriers.
On the contrary, in ER-negative diseases no significant OS differences were observed across all PVs (BRCA1, BRCA2, ATM, CHEK2, PALB2) These results reinforce how tumor biology and endocrine sensitivity may drive prognosis in ER+ diseases!
In our analysis presented at ASCO24 and published in Annals Oncology we evaluated prognosis of young patients (<40y) affected by BC and harboring BRCA1 and BRCA2 PVs We included >4,500 young BRCA carriers, and these were the main findings:
– BRCA carriers with HR+ disease had similar prognosis of carriers with HR- disease
– BRCA2 carriers had worse prognosis (particularly BCSS) in year >5 from diagnosis
– Carriers with Luminal A-like diseases had poorer DFS than all the other subtypesBoth studies question the prognostic advantage of HR-positivity in BRCA carriers
HR+ BC in BRCA carriers (especially BRCA2) behave more aggressively than in sporadic cases
Time to re-evaluate (escalate) treatments in BRCA carriers with HR+ BC?”
Title: Impact of hormone receptor status and tumor subtypes of breast cancer in young BRCA carriers
Read OncoDaily’s Special Articles about ASCO 2025:
Highlights from ASCO 2025 Day 1
Highlights from ASCO 2025 Day 2
A. Di Meglio
A. Fabi
A. Ferrari
A. Fontana
A. Matikas
A. Rodriguez Hernandez
A. Toss
A.H. Partridge
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ASCO 2025
ASCO25
C. Rousset-Jablonski
C. Vernieri
cancer
CARRIERS study
Clinical Science Symposium
D. Aguilar-y Méndez
E. Agostinetto
E. Blondeaux
E. Carrasco
E. de Azambuja
E. Sokolović
F. Puglisi
F.J. Couch
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K. Punie
K.A. Phillips
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Luca Arecco
M. Bruzzone
M. Ceppi
M. Lambertini
M. Rozenblit
M.V. Dieci
N. Lopetegui-Lia
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R. Bernstein-Molho
R. Duchnowska
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