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Denis Wirtz: The recruitment of monocytes fuel tumor growth via MAPK pathway activation
Photo of Denis Wirtz from engineering.jhu.edu
Jul 22, 2024, 13:11

Denis Wirtz: The recruitment of monocytes fuel tumor growth via MAPK pathway activation

 Denis Wirtz, Vice Provost of Research at Johns Hopkins University, shared on X about recent paper by Wenxuan Du et al., commenting:

“Our work suggests that macrophages are not recruited into a tumor, but are enriched through the recruitment of monocytes. These monocytes, not the macrophages that they differentiate into, fuel tumor growth via MAPK pathway activation. We identify tumor-associated monocytes (TAMo’s) that, unlike TAMΦ’s, display a dramatically enhanced migration induced by the TME and promote cancer cell proliferation

Read about migration capability of macrophages vs. monocytes.”

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Journal: The Preprint Server for Biology

Author: Wenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin, Denis Wirtz

Denis Wirtz: The recruitment of monocytes fuel tumor growth via MAPK pathway activation

Source: Denis Wirtz/X

André Forjaz Bryan Zhou cancer David E. Sanin Denis Wirtz MAPK pathway OncoDaily Oncology tumor-associated monocytes Wenxuan Du
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