Vivek Subbiah, Chief of Early-Phase Drug Development at the Sarah Cannon Research Institute, has highlighted recent studies that offer a broad perspective on where oncology is headed. Covering topics ranging from immunotherapy and breast cancer to colorectal cancer, the gut microbiome, DNA repair, bacterial engineering, and next-generation precision oncology, the collection showcases research that is advancing both scientific understanding and clinical practice.
Below is a selection of the 10 papers, each offering unique insights into emerging discoveries, innovative therapeutic strategies, and evolving concepts that are shaping the future of cancer research and patient care.
“At 200+ years, the bowhead whale outlives every other mammal and tips the scales at 80,000 kg. Yet it rarely gets cancer. A new Nature paper digs into the mystery, spotlighting unique DNA‑repair genes with implications for aging and cancer biology. Peto’s paradox keeps getting more interesting.”
Title: Evidence for improved DNA repair in the long-lived bowhead whale
Authors: Denis Firsanov, Max Zacher, Xiao Tian, Todd L. Sformo, Yang Zhao, Gregory Tombline, J. Yuyang Lu, Zhizhong Zheng, Luigi Perelli, Enrico Gurreri, Li Zhang, Jing Guo, Anatoly Korotkov, Valentin Volobaev, Seyed Ali Biashad, Zhihui Zhang, Johanna Heid, Alexander Y. Maslov, Shixiang Sun, Zhuoer Wu, Jonathan Gigas, Eric C. Hillpot, John C. Martinez, Minseon Lee, Alyssa Williams, Abbey Gilman, Nicholas Hamilton, Ekaterina Strelkova, Ena Haseljic,
Avnee Patel, Maggie E. Straight, Nalani Miller, Julia Ablaeva, Lok Ming Tam, Chloé Couderc, Michael R. Hoopmann, Robert L. Moritz, Shingo Fujii, Amandine Pelletier, Dan J. Hayman, Hongrui Liu, Yuxuan Cai, Anthony K. L. Leung, Zhengdong Zhang, C. Bradley Nelson, Lisa M. Abegglen, Joshua D. Schiffman, Vadim N. Gladyshev, Carlo C. Maley, Mauro Modesti, Giannicola Genovese, Mirre J. P. Simons, Jan Vijg, Andrei Seluanov, Vera Gorbunova
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“Neoadjuvant Paclitaxel, Trastuzumab, and Pertuzumab for Stage II to III, ERBB2-Positive Breast Cancer.”
Title: Neoadjuvant Paclitaxel, Trastuzumab, and Pertuzumab for Stage II to III, ERBB2-Positive Breast Cancer
Authors: Paolo Tarantino, Tianyu Li, Esther Ritah Ogayo, Tasnim Rahman, Molly K. DiLullo, Ashka Patel, Sherif El-Refai, Charles Abbott, Bailiang Li, Sean M. Boyle, Richard O. Chen, Neelam V. Desai, Laura M. Spring, Nadine M. Tung, Natalie Sinclair, Meredith Faggen, Michael Constantine, Tari A. King, Ian E. Krop, Nabihah Tayob, Elizabeth A. Mittendorf, Sara M. Tolaney, Eric P. Winer, Heather A. Parsons, Adrienne G. Waks
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“Georgia O’Keeffe, Hannah Wilke, and Choosing One’s Own Narrative.”
Title: Georgia O’Keeffe, Hannah Wilke, and Choosing One’s Own Narrative-Sovereignty
Author: Gilberto Lopes
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“Bacterial engineering for cancer therapy | Nature Cancer.“
Title: Bacterial engineering for cancer therapy
Authors: Noah Chen, Zaofeng Yang, Nicholas Arpaia
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“A high-MAPK, low-WNT cell state drives metastatic dissemination in colorectal cancer | Nature Cancer.”
Title: A high-MAPK, low-WNT cell state drives metastatic dissemination in colorectal cancer
Authors: Melanie Heinlein, Ginny X. Li, Noelyn Kljavin, Amanda R. Moore, Brian Biehs, Liming Tao, Soufiane Boumahdi, Farnaz Mohammadi, Minyi Shi, Yuxin Liang, Hartmut Koeppen, Nicolò Riggi, Robert Piskol, Frederic J. de Sauvage
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“A renaissance in targeting the PI3K/AKT/mTOR pathway | Nature Reviews Drug Discovery.”
Title: A renaissance in targeting the PI3K/AKT/mTOR pathway
Authors: Sarah E. Conduit, Neil Vasan, Jennifer R. Brown, Matthew W. D. Perry, Bart Vanhaesebroeck
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“Targeting claudins in cancer | Nature Reviews Drug Discovery.”
Title: Targeting claudins in cancer
Authors: Yuki Niwa, Shunsuke Matsushita, Izuma Nakayama, Masuo Kondoh
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“Pharmacologic Inhibition of PMS2 Induces MMR Deficiency and Response to Immune Checkpoint Blockade.”
Title: Pharmacologic Inhibition of PMS2 Induces MMR Deficiency and Response to Immune Checkpoint Blockade
Authors: Julian Blagg, Philippe Riou, Alexia Hervieu, Eleonora Piumatti, Maria T. Rodriguez-Plata, Paolo Battuello, Adam Peall, Vito Amodio, Pietro Paolo Vitiello, Daniel J.H. Nightingale, Ruzica Bago, Paige Tongue, Tessa Slater, Kalpesh Parmar, Pradip Patel, Javier Rodríguez González, David E. Clark, Gareth W. Langley, Charles Nichols, Alba Guarné, Paul C.M. Winship, Matthew Baker, Martin Drysdale, Giovanni Germano, Alberto Bardelli
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“Beyond one gene, one target: Next-generation precision oncology: Trends in Cancer.”
Title: Beyond one gene, one target: Next-generation precision oncology
Authors: Vivek Subbiah and Razelle Kurzrock
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“Gut microbiome is associated with recurrence-free survival in patients with resected high-risk melanoma receiving adjuvant immune checkpoint blockade: Cell.”
Title: Gut microbiome is associated with recurrence-free survival in patients with resected high-risk melanoma receiving adjuvant immune checkpoint blockade
Authors: Mykhaylo Usyk, Richard B. Hayes, Rob Knight, Antonio Gonzalez, Huilin Li, Iman Osman, Jeffrey S. Weber, Jiyoung Ahn
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Other articles featuring Vivek Subbiah on OncoDaily.
Written by Mane Hovhannisyan, Editor at OncoDaily.