Ron DePinho, Professor of Department of Cancer Biology, Division of Discovery Science at MD Anderson Cancer Center, shared a post on LinkedIn:
“I am proud to recognize the outstanding work of Pingping Hou from the Rutgers Cancer Institute.
Her study, published in Cancer Discovery, demonstrated how pancreatic cancer can remodel the tumor microenvironment to bypass KRAS dependency.
The research identified tumor-associated macrophages as active drivers of therapeutic resistance and uncovered a druggable stromal–immune signaling circuit in pancreatic ductal adenocarcinoma (PDAC).
The findings suggest that transforming growth factor beta (TGF-β) produced within the tumor microenvironment provides trophic support to cancer cells following KRAS extinction, offering new insights into mechanisms of resistance and potential therapeutic strategies.”
Title: Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer
Authors: Pingping Hou, Avnish Kapoor, Qiang Zhang, Jiexi Li, Chang-Jiun Wu, Jun Li, Zhengdao Lan, Ming Tang, Xingdi Ma, Jeffrey J. Ackroyd, Raghu Kalluri, Jianhua Zhang, Shan Jiang, Denise J. Spring, Y. Alan Wang, Ronald A. DePinho
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