Cancer Discovery

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January, 2025
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Cancer Discovery
Jan 16, 2025, 10:13 | Blog
Elizabeth McKenna: The January issue of Cancer Discovery is now online
Elizabeth McKenna, Executive Director of Cancer Discovery at AACR, shared a post on X "The…
Jan 15, 2025, 15:06 | Insight
Vivek Subbiah: Pleasure to meet Lisa Situ
Vivek Subbiah, Chief of Early-Phase Drug Development at the Sarah Cannon Research Institute (USA), shared…
Jan 10, 2025, 16:09 | Insight
How do the tumor genome, transcriptome, and TME jointly evolve in ccRCC? - Turajlic Lab
Turajlic Lab shared a post on X: "How do the tumor genome, transcriptome, and TME jointly…
Jan 4, 2025, 15:27 | Science
Ashwin Kishtagari: How non-selective β-blockers impair hematopoietic regeneration after HCT
Ashwin Kishtagari, Assistant Professor at Vanderbilt-Ingram Cancer Center, shared a post on X about a…
Dec 25, 2024, 22:43 | History
Raffaele Colombo: A record 77 new ADCs entered clinical development in 2024
Raffaele Colombo, Associate Director of Medicinal Chemistry at Zymeworks Inc., shared a post on X…
Dec 25, 2024, 18:18 | Blog
A classical epithelial cancer cell state drives resistance to KRAS inhibition in Pancreatic Cancer - NCI Division of Cancer Biology
NCI Division of Cancer Biology shared a post on X: “Using reporter systems and preclinical…
Dec 23, 2024, 12:33 | Science
Elizabeth McKenna: Multimodal Spatial Profiling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
A recent paper by Tanjina Kader, Post Doctoral Fellow at Harvard Medical School, published in…
Dec 22, 2024, 14:32 | Science
10 Top Translational Papers in GU Oncology suggested by Toni Choueiri
Toni Choueiri, Director of the Lank Center for GU Oncology at Dana-Farber Cancer Institute, shared…
Dec 20, 2024, 21:15 | Blog
Cancer Discovery: Nominations for the Cancer Discovery Early Career Award
Cancer Discovery shared a post on X: "Reminder—nominations for the Cancer Discovery Early Career Award…
Dec 19, 2024, 14:34 | Insight
TREM2+ Multinucleated Giant Macrophages as a Prognostic Marker in Head and Neck Squamous Cell Carcinoma
Cancer Discovery shared a post on X: "From the December issue: TREM2-expressing Multinucleated Giant Macrophages Are…
Dec 18, 2024, 18:12 | Blog
Divij Verma: The increased risk of pre-leukemic clonal hematopoiesis in 9/11-exposed first responders
Divij Verma, Research Assistant Professor at Albert Einstein College of Medicine, shared a post on…
Dec 18, 2024, 08:21 | Blog
Cancer Discovery - Reflections on Advances in Cancer Research in 2024
Cancer Discovery shared on X: "Reflections on Advances in Cancer Research in 2024 | Cancer…
Dec 14, 2024, 13:22 | Insight
Cancer cell migration patterns in a new preclinical model - NCI Division of Cancer Biology
NCI Division of Cancer Biology shared a recent article by Ryan N. Serio on X:…
Dec 11, 2024, 05:14 | Insight
Androgen Receptor Inhibition Increases MHC Class I Expression in Prostate Cancer
Elizabeth McKenna, Executive Director of Cancer Discovery at the American Association for Cancer Research, shared…
Dec 9, 2024, 13:26 | Insight
First-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C
Daniel Gerlach, Associate Scientific Director, Computational Biology Oncology at Boehringer Ingelheim, shared a recent article…
Dec 8, 2024, 04:41 | Insight
Elizabeth McKenna: Ancestral Differences in Anticancer Treatment Efficacy by Mei Luo
Elizabeth McKenna, Executive Director of Cancer Discovery at the American Association for Cancer Research, shared…
Dec 4, 2024, 19:07 | Insight
Itai Yanai: Reflections on Advances in Cancer Research in 2024
Itai Yanai, Professor in the Department of Biochemistry and Molecular Pharmacology at NYU Langone Health,…
Dec 4, 2024, 18:59 | Insight
Elizabeth McKenna: The December issue of Cancer Discovery is online
Elizabeth McKenna, Executive Director of Cancer Discovery at AACR, shared a post on X by…
Nov 10, 2024, 03:48 | Insight
Tracing 40 years of breakthroughs and challenges in ADC development
Dana-Farber’s Breast Oncology Center shared a post on X: “Don't miss this recently published Cancer…
Nov 7, 2024, 15:29 | Insight
Angelo D'Alessandro: New mechanism of protection from cuproptosis in cRCC
Angelo D'Alessandro, Professor at the University of Colorado Anschutz Medical Campus, shared on X: “Now…
Nov 5, 2024, 15:59 | Blog
Elizabeth McKenna: The November issue of Cancer Discovery is now online
Elizabeth McKenna posted on X: "I'm so excited that the November issue of Cancer Discovery…
Oct 27, 2024, 16:50 | Blog
Epigenetic hallmarks affected in human cancer, suggested by Gianluca Sbardella
Gianluca Sbardella, Professor at Università Salerno, shared a post on X: "An excellent article on…
Oct 25, 2024, 17:29 | Blog
Elizabeth McKenna: What explains the differences in cancer prevalence across multicellular species?
Elizabeth McKenna, Executive Director of Cancer Discovery at the AACR, shared on LinkedIn: "What explains…
Oct 25, 2024, 16:47 | Blog
Key milestones and insights from the evolution of antibody-drug conjugates - Zymeworks Inc.
Zymeworks Inc. shared a post on Linkedin: ''We're proud to share a recent publication in…
Oct 25, 2024, 13:16 | Insight
Elizabeth McKenna: An overview of the past 4 decades of development of ADC’s
Elizabeth McKenna, Executive Editor of Cancer Discovery at American Association for Cancer Research, shared on…
Oct 24, 2024, 12:54 | Insight
Biologic and clinical analysis of childhood gamma delta T-ALL - Cancer Discovery
Cancer Discovery shared a post on X about a recent paper published by Shunsuke Kimura…
Oct 23, 2024, 14:45 | Blog
Paolo Tarantino: How do we build a new generation of safer and more active ADCs for treating cancer
Paolo Tarantino and Raffaele Colombo shared posts on X, about recent paper published in Cancer…
Oct 22, 2024, 14:57 | Insight
Joseph Grossman: Botensilimab is effective against Tumors Poorly Responsive to Conventional Immunotherapy
Joseph Grossman, Vice President of Early Clinical Development at Agenus,  shared a post on LinkedIn: "The…
Oct 18, 2024, 15:37 | Insight
Margaret Foti has received the 2024 Beacon Award for Women Leaders in Oncology
On October 18, 2024, during the Global Summit and Award Ceremonies for Cancer Research and…
Oct 17, 2024, 15:16 | Insight
Manel Esteller: Bidirectional impact of epigenetics and genetics
Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, shared a post on X…
Oct 14, 2024, 13:10 | Blog
Miguel Bronchud: Astrocyte-dependent local immunosuppression in brain metastasis
Miguel Bronchud, Co-Founder of Regenerative Medicine Solutions, shared on LinkedIn: "Spanish National Center for Cancer…
Oct 11, 2024, 15:08 | Blog
The Evolutionary Forest of Pancreatic Cancer, suggested by Anirban Maitra
Anirban Maitra shared a post on X: "New Open Access in Cancer Discovery, Katelyn Mullen graduate…
Oct 11, 2024, 04:54 | Insight
The EACR's Highlights in Cancer Research
The European Association for Cancer Research (EACR) shared the latest highlights in recent cancer research…
Oct 8, 2024, 17:17 | Insight
Elizabeth McKenna: Cell State Heterogeneity and Intercellular Transfer in glioblastoma
Elizabeth McKenna recently shared an article by Vamsi Mangena et al. published in Cancer Discovery.…
Oct 8, 2024, 15:49 | Insight
Manel Esteller: Epigenetic Hallmarks in Cancer in Cancer Discovery
Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, shared a post on X:…
Oct 7, 2024, 09:09 | Blog
Elizabeth McKenna: The October issue of Cancer Discovery is out
Elizabeth McKenna shared a post on X: "Out today in the October issue of Cancer Discovery:…
Oct 1, 2024, 18:18 | Insight
Elizabeth McKenna: Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers
Elizabeth McKenna shared a post on X about a recent paper by Jamie Medina et…
Oct 1, 2024, 15:50 | Insight
Anirban Maitra: Do multiple tumor promoting pathways converge on a common family of kinases?
Anirban Maitra shared on X: “Provocative Cancer Discovery paper from Nabeel Bardeesy, Mass General Cancer…
Sep 30, 2024, 16:38 | Insight
New work on how DNAJB1-PRKACA fusion drives Fibrolamellar Carcinoma
Ilaria Gritti shared a post on X, by Elizabeth McKenna, about a recent paper published…
Sep 27, 2024, 14:49 | Insight
The EACR Board has selected the latest highlights in recent cancer research papers
The European Association for Cancer Research shared on X: "The EACR Board has selected the…
Sep 19, 2024, 09:23 | Insight
Jessica Lin: Preclinical development and proof-of-concept clinical activity of NVL-655
Jessica Lin shared a post on LinkedIn: "We are pleased to share this article out today…
Sep 9, 2024, 17:52 | Blog
Michael Rothenberg: A next generation BRAF Inhibitor shows promise in treatment refractory cancer patients
Michael Rothenberg, Chief Medical Officer at Insitro, shared on LinkedIn: "The Pfizer, Pfizer Boulder Research Unit,…
Sep 7, 2024, 10:15 | Insight
Leo Meriranta: KLHL6 targeting the B-cell receptor and lymphoma mutations
Leo Meriranta shared on X: “Friends! I am super-excited to share our story on KLHL6…
Sep 2, 2024, 09:01 | Insight
Mrinal Patnaik: ARNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
Mrinal Patnaik, Physician Scientist with the Division of Hematology, Department of Internal Medicine at Mayo…
Sep 2, 2024, 07:05 | Insight
Samuel Bakhoum: The role of mitochondria and free radicals in promoting the collapse of cancer micronuclei
Samuel Bakhoum, Associate Member (Professor) in HOPP and Radiation Oncology, Memorial Sloan Kettering Cancer Center,…
Aug 29, 2024, 17:26 | Blog
Natasha Rekhtman: Chromothripsis-mediated Small Cell Lung Cancer
Natasha Rekhtman posted on X: "Hot off the press from team Memorial Sloan Kettering Cancer…
Aug 14, 2024, 18:18 | Insight
Epigenetic and Oncogenic Inhibitors target KRAS-mutant Colorectal Cancers
Elizabeth McKenna shared a post on X about a recent paper by Patrick Loi et…
Aug 10, 2024, 13:39 | Insight
Botensilimab’s effectiveness against tumours poorly responsive to conventional immunotherapy
Justin Stebbing shared a post on LinkedIn:  “Congratulations to Dhan Chand and the Agenus team…
Aug 6, 2024, 11:02 | Blog
Elizabeth McKenna: The August issue of Cancer Discovery is now online
Elizabeth McKenna shared a post on X: "The August issue of Cancer Discovery is now online!…
Jul 31, 2024, 15:50 | Blog
Juan Cubillos-Ruiz: Iron chelation therapy unleashes innate immune responses that control Ovarian Cancer
Juan Cubillos-Ruiz,  Associate Professor for Infection and Immunology at Well Corner Medicine, shared on X:…
Jul 31, 2024, 10:17 | Opinion
Tito Sandoval: Cubillos-Ruiz Lab's latest study about iron chelation therapy for ovarian cancer
Tito Sandoval, Senior Scientist at Washington University School of Medicine in St. Louis, shared on X…
Jul 28, 2024, 12:52 | Insight
Jaehyuk Choi: A tour-de-force cellular and transcriptional dissection of Merkel cell carcinoma
Jaehyuk Choi, Associate Professor at Northwestern University, shared a post on X about a recent…
Jul 28, 2024, 12:47 | Insight
MARK2/MARK3 Kinases Are Catalytic Co-dependencies of YAP/TAZ in Human Cancer
Elizabeth McKenna, Executive Editor of Cancer Discovery, shared a post on X about a recent…
Jul 23, 2024, 10:34 | Insight
The EACR's highlights in cancer research
The European Association for Cancer Research (EACR) shared on X: “The EACR's Highlights in Cancer…
Jul 20, 2024, 10:27 | Blog
Elizabeth McKenna: The SCRUM-MONSTAR Cancer-Omics Ecosystem
Elizabeth McKenna shared a post on X: ''Now online in Cancer Discovery: The SCRUM-MONSTAR Cancer-Omics…
Jul 19, 2024, 22:19 | Insight
Yüksel Ürün: Congratulations all new participants of the ASCO Leadership Development Program!
Yüksel Ürün shared a post by Miriam Knoll, on X, adding: "Congratulations to you and…
Jul 16, 2024, 03:13 | Blog
Haniel Araujo: Efficacy of the novel RAS(ON) in KRASG12C mutant NSCLC
Haniel Araujo, Thoracic and Head and Neck Medical Oncology Fellow at MD Anderson Cancer Center, shared…
Jul 14, 2024, 15:02 | Insight
Bruno Giotti: Multiple gene programs and cellular subpopulations associated with patient prognosis in pleural mesothelioma
Bruno Giotti, Postdoctoral Researcher at Icahn School of Medicine at Mount Sinai, shared a post…
Jul 14, 2024, 04:21 | Insight
Elizabeth McKenna: 4 papers with variations on the theme of cancer cell plasticity as a mechanism of resistance to KRAS inhibition
Norbert Kraut, Global Head of Cancer Research Boehringer Ingelheim, shared a post by Elizabeth McKenna,…
Jul 11, 2024, 14:56 | Insight
Simona Cristea: The multi-facet process of resistance to KRAS inhibitors in pancreatic cancer
Simona Cristea, Head of Data Science at Hale Center for Pancreatic Cancer, shared a post by…
Jul 7, 2024, 16:08 | Insight
Tumor Microenvironment Gradients in Pleural Mesothelioma
Elizabeth McKenna shared on X: "Now online in Cancer Discovery: Single-cell View of Tumor Microenvironment Gradients…
Jul 5, 2024, 16:30 | Insight
CAR NK cells with CD28 costimulation improved cell persistence and antitumor activity
Adding CD28 costimulation to cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cells targeting…
Jul 5, 2024, 14:17 | Blog
Whijae Roh: The history of chromosomal instability in genome doubled tumors
Whijae Roh, Senior Computational Biologist at Pfizer, shared a post by Elizabeth McKenna, on X: "The history…
Jul 5, 2024, 13:43 | Insight
Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
‘Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth.’ This paper was…
Jul 4, 2024, 14:44 | Insight
Elizabeth McKenna: The July issue of Cancer Discovery is now online
Elizabeth McKenna shared a post on LinkedIn: “The July issue of Cancer Discovery is now online!…
Jul 4, 2024, 11:09 | Insight
Impact of Antibiotic Preconditioning on Microbiome and Immunity
Anirban Maitra shared on X: "The July issue of Cancer Discovery is online! Featuring a…
Jun 30, 2024, 13:42 | Blog
Sumanta K. Pal discusses CD70-Targeted Allogeneic CAR T-Cell Therapy for ccRCC - Cancer Discovery
Cancer Discovery shared on X: "Published by a nonprofit professional society, the journal enhances knowledge…
Jun 30, 2024, 05:23 | Blog
María Mayán: How and why becoming an editor
María Mayán, Research Group Leader at CINBIO, shared on X/Twitter: . "Lunch session with editors:…
Jun 28, 2024, 06:45 | Positive
Patrick Hwu: Moffitt Cancer Center is at the forefront of cancer discovery
Patrick Hwu shared on X: "Bioengineering is vital to making strides in cancer discovery, and…
Jun 25, 2024, 12:52 | Blog
Tali Lev: Excited to attend the ⁦Metastasis Research Society 20th Biennial meeting
Tali Lev, Senior Editor at Cancer Discovery, made the following post on X: . "Hi from…
Jun 25, 2024, 12:48 | Blog
Engaging with the community at the forefront of cancer science and medicine - Cancer Discovery
Cancer Discovery shared on X:  . “Engaging with the community at the forefront of cancer…
Jun 23, 2024, 13:22 | Insight
Katy Rezvani: Exciting research on CD70-targeting CAR NK cells
Katy Rezvani shared Elizabeth McKenna's post on X, adding: "Many congratulations to our Dr. Sunil…
Jun 18, 2024, 14:39 | Insight
Personalised support from experienced in-house editors - AACR Journals
Elizabeth McKenna shared a post by AACR Journals on LinkedIn, adding: “Reach out to the Cancer…
Jun 9, 2024, 06:40 | Insight
W. Gregory Sawyer: Engineering Cancers End
W. Gregory Sawyer, Moffitt Cancer Center Chief BioEngineering Officer, shared on X: “Engineering Cancers End.…
May 30, 2024, 06:33 | Career
Bailee Sliker: I start a new chapter as an Oncology Scientist/Medical Writer at NCCN
Bailee Sliker, Oncology Scientist/Medical Writer at the National Comprehensive Cancer Network (NCCN), shared on X:…
May 4, 2024, 16:54 | Insight
Elizabeth McKenna: The May issue of Cancer Discovery
Elizabeth McKenna shared on LinkedIn: "The May issue of Cancer Discovery is now online! The…
May 4, 2024, 10:27 | Insight
Paolo Tarantino: HER2 is about to change again
Paolo Tarantino shared a previous post of him on X and added: "HER2 is about…
May 2, 2024, 23:03 | Career
Steven Kridel: I’m starting a new position as Chair of Department of Cancer Biology at Wake Forest University School of Medicine!
Steven Kridel, Chair, Department of Cancer Biology at Wake Forest University School of Medicine, made…
May 1, 2024, 11:57 | Blog
Direna Alonso-Curbelo receives Cancer Discovery Early Career Award
Cancer Discovery shared on X/Twitter: "Congratulations, Direna Alonso-Curbelo, on the inaugural Cancer Discovery Early Career Award!…
Apr 20, 2024, 06:57 | Insight
Read an In Focus article by Kimryn Rathmell from the latest issue - Cancer Discovery
Cancer Discovery shared a post on X: “Read an In Focus article by Kimryn Rathmell…
Apr 17, 2024, 00:52 | Insight
UHN Research - Can a blood sample be used to predict patient outcomes to cancer immunotherapy drug pembrolizumab?
UHN Research shared on their LinkedIn: "Can a blood sample be used to predict patient…
Apr 14, 2024, 14:08 | Blog
Danielle Carnival: About Biden Cancer Moonshot progress and global commitment in Cancer Discovery
Danielle Carnival, Deputy Assistant to President Biden for the Cancer Moonshot, shared on X/Twitter: "At the…
Apr 14, 2024, 06:54 | Opinion
Kimryn Rathmell: The National Cancer Plan is meant to drive innovation in cancer research
Kimryn Rathmell, Director of the National Cancer Institute, shared on X/Twitter: "The National Cancer Plan…
Apr 11, 2024, 17:38 | Insight
Vivek Subbiah: Thrilled to be featured in AACR’s special issue of Cancer Discovery
Vivek Subbiah shared a post on X: “Thrilled to be featured in American Association for…
Apr 11, 2024, 15:23 | Drugs
Piotr Wysocki: Adagrasib and cetuximab in KRAS G12C-mutated colorectal cancer is a safe and active
Piotr Wysocki, Professor of Medicine and Head of the Department of Oncology at Jagiellonian University…
Apr 11, 2024, 12:10 | Blog
CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma, by Sumanta K. Pal et al - Cancer Discovery
Cancer Discovery shared on X/Twitter: "Just published with the AACR24 Clinical Plenary presentation: CD70-Targeted Allogeneic CAR…
Apr 11, 2024, 06:46 | Opinion
Maria Natalia Gandur Quiroga: The Hallmarks of Precancer
Maria Natalia Gandur Quiroga shared a post on X: "The Hallmarks of Precancer. AACR Journals,…
Apr 10, 2024, 09:09 | Blog
Vivek Subbiah: Super delighted to meet the amazing Elizabeth McKenna, Executive Editor of Cancer Discovery
Vivek Subbiah shared on X/Twitter: "Super delighted to meet the amazing Elizabeth McKenna, Executive Editor…
Apr 8, 2024, 22:24 | Insight
NSCLC's Immune Landscape: A Comprehensive Study of the Tumor Microenvironment
A recent study, “Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical…
Apr 8, 2024, 15:43 | Blog
Luis Diaz: The most recent issue of Cancer Discovery features our prescient commentaries about the future of cancer research
Luis Diaz, Head of Division of Solid Tumor Oncology at Memorial Sloan Kettering Cancer Center,…
Apr 7, 2024, 23:28 | Insight
Biagio Ricciuti: MET kinase domain mutations as novel & targetable alterations in NSCLC and other cancer types
Biagio Ricciuti, Medical Oncologist at Dana-Farber Cancer Institute, shared on X: "Our collaborative effort to…
Apr 6, 2024, 14:56 | Insight
Kimryn Rathmell: My Cancer Discovery commentary for a new perspective on the National Cancer Plan
Kimryn Rathmell, Director of the National Cancer Institute, recently shared on X: "Ready for AACR24?…
Apr 6, 2024, 12:55 | Societies
Productive Peer Review: Improving Science while Avoiding Pitfalls session at AACR24
The American Association for Cancer Research (AACR) shared a post on X/Twitter: "Productive Peer Review:…
Apr 6, 2024, 08:34 | Opinion
Kimryn Rathmell: My Cancer Discovery commentary for a new perspective on the National Cancer Plan
Kimryn Rathmell, Director of NCI, shared on X/Twitter: "Ready for AACR24? Before we hit the…
Mar 20, 2024, 23:02 | Blog
Attending the NIH-CZI Junior Investigators Atlas Builders Meeting? - Cancer Discovery
Cancer Discovery made the following post on X: "Are you attending the NIH-CZI Junior Investigators…
Mar 8, 2024, 19:03 | Insight
Lea Monteran: TIGIT blockade with MDSC inhibition may be a novel and promising therapeutic strategy to treat bone metastasis
Lea Monteran, Ph.D. student at Tel Aviv University, shared on X/Twitter: "I am excited to…
Feb 27, 2024, 19:29 | Blog
Eric Stutheit-Zhao: A blood sample can track immunotherapy response
Eric Stutheit-Zhao, Resident Doctor at Department of Radiation Oncology, University of Toronto, shared a post…
Feb 24, 2024, 16:50 | Blog
Toni Choueiri: New insights from the JAVELIN Renal 101 trial in RCC in Cancer Discovery
Toni Choueiri, Professor of Medicine at Harvard Medical School and Director of the Lank Center for…
Feb 1, 2024, 13:52 | Blog
Yuki Saito: A pan-cancer landscape of driver alterations and their clinical actionability in Japanese patients
Yuki Saito, Postdoctoral researcher at Keisuke Kataoka Laboratory, shared a post by Keisuke Kataoka Laboratory…
Jan 18, 2024, 16:08 | Insight
Yüksel Ürün: Exciting news for cancer patients and researchers alike!
Yüksel Ürün, Professor at the Department of Medical Oncology at the Ankara University School of…
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