Rishabh Jain, Medical Oncologist at AIIMS, shared a post on X:
“Breast reconstruction de-escalation is here.
The PREPEC trial suggests that pre-pectoral implant placement may improve long-term patient-reported chest well-being versus traditional sub-pectoral reconstruction after mastectomy.
Key findings:
- Randomized trial after nipple/skin-sparing mastectomy
- Pre-pectoral vs sub-pectoral implants
- Better physical well-being at 24 months with pre-pectoral approach
24-month chest well-being score:
- Pre-pectoral: 79.2
- Sub-pectoral: 74.3
- Difference: +4.8 points (p=0.01)
But there’s a tradeoff. Pre-pectoral reconstruction also increased the risk of unplanned expander/implant loss or replacement.
This is where modern breast oncology is heading:
- Less aggressive surgery.
- More patient-centered outcomes.
- But nuanced decision-making still matters.
Will pre-pectoral implants become the new default for selected patients after mastectomy?”
Title: Surgical de-escalation of implant-based breast reconstruction (IBBR) after mastectomy for breast cancer treatment or prevention: The international randomized phase III PREPEC trial (OPBC-02).
Authors: Walter Weber, Ruichao Shi, Zoltan Matrai, Joerg Heil, Eduardo Gonzalez, Cicero Urban, Vesna Bjelic-Radisic, Yoav Gronovich, Florian Fitzal, Sherko Kuemmel, Amelia Chiorescu, Régis R. Paulinelli, Yoon S. Chun, Alexandra Schulz, Meredith M. Regan, Martin Haug, Martin Heidinger, Elisabeth A. Kappos, Jana de Boniface, Yves Harder
Read the Full Abstract.
Other articles featuring Rishabh Jain on OncoDaily.
