The IASLC 2025 Hot Topic in Basic and Translational Science: Unraveling Precancer and Early-Stage Lung Cancer meeting is a three-day event in Tokyo, Japan, dedicated to advancing the understanding and treatment of early lung cancer.
The meeting focuses on the molecular, genomic, transcriptomic, and immune mechanisms of early lung carcinogenesis. It aims to bridge the gap between basic science and clinical application by exploring emerging biomarker and diagnostic innovations (including liquid biopsies and AI) and discussing novel therapeutic pathways like targeted therapies and immunotherapy for the earliest stages of the disease.
Triparna Sen, Professor at The Ohio State University, shared some insights from the event:
Spatial Insights into Tumor Diversity in SCLC
“Fascinating science from Dr Chaoqiang Deng of Fudan University Shanghai Cancer Hospital on integrative spatial analysis revealing tumor heterogeneity and immune colony niches in small cell lung cancer.”
Advances in NSCLC Liquid Biopsies
“Fantastic talk by Dr. Tom John from the Peter MacCallum Cancer Centre on current and future applications of liquid biopsies in NSCLC.”
MRD Applications in Early-Stage Lung Cancer
“Excellent presentation by Jia Tao Zhang from the Guangdong Lung Cancer Institute on the application of MRD in early stage lung cancer. Clear impact for clinical translation.”
Dr. Ming Tsao on Prognostic Biomarkers in NSCLC
“Masterclass by Dr. Ming Tsao of Princess Margaret Cancer Centre on histology and molecular biomarkers for prognosis in early stage NSCLC. Amazing leadership by Dr. Tsao in this space.”
Dr. Ehab Billatos on Swab-Based Screening
“Excellent and engaging session by Dr. Ehab Billatos of Boston University on nasal or buccal swap-based detection approaches. Exciting direction for non-invasive screening.”
Circulating miRNA as Early Lung Cancer Biomarkers
“Great presentation by Fabrizio Bianci from IRCCS Casa Sollievo della Sofferenza Foundation on circulating miRNA. Strong promise for early lungcancer biomarkers.”
Jacky Lam on Precision Early Detection
“Insightful talk by Jacky Lam of the Chinese University of Hong Kong on the cell-free fragmentome assay. A compelling step toward precision earlydetection.”
Wei Jie Seow on Metabolite-Based Lung Cancer Insights
“Exciting data shared by Wei Jie Seow from the National University of Singapore Global Asia Institute on pre-diagnostic circulating metabolites and lungcancer risk from the COMETS consortium. Impressive international effort.”
Dr. Mitsudomi on Perioperative NSCLC Management
“Engaging and highly informative talk by Dr. Tetsuya Mitsudomi of Kindai University on perioperative strategies for NSCLC without AGA. A true leader in thoracic oncology and an invaluable conference co-chair.”
Biological Insights in Neoadjuvant Therapy for Lung Cancer
“Fascinating talk by my conference co-chair, Dr. Aaron Tan from the National Cancer Center Singapore, on biological insights in neoadjuvant therapy for early stage lung cancer.”
Pathologic Response as a Guide in Early Lung Cancer
“Excellent presentation by Dr. Yasushi Yatabe from the National Cancer Center Singapore on pathologic response as both an outcome and predictor guiding therapeutic choices in early-stage lung cancer.”
Perioperative Approaches for Oncogene-Driven NSCLC
“Great session by Dr. Sun Min Lim of Severance Hospital at Yonsei University Health System on perioperative approaches for non-small cell lungcancer with oncogenic addiction. She highlights the challenges and the ongoing efforts in this space.”
IL-1 Signaling in Pulmonary Nodule Evolution
“Exciting talk by Dr. Matthew Park of the Icahn School of Medicine at Mount Sinai on myeloid IL-1 signaling driving the precancer to cancer evolution of human pulmonary nodules. Impressive mechanistic insights.”
Inside “IASLC 2025 Hot Topic in Basic and Translational Science” with Triparna Sen
