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Hassan R. Hashmi,
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Hassan R. Hashmi: Exciting New Evidence in Rectal Cancer Care

Hassan R. Hashmi, General and Colorectal Surgeon at Las Vegas Surgical Associates, shared a post on LinkedIn about a recent article by Alessio Amatu et al. published in The Lancet Oncology:

“Exciting new evidence in rectal cancer care.

A recent multicenter phase 2 trial (NO-CUT) published in The Lancet Oncology shows that for patients with stage II–III pMMR/MSS rectal cancer, total neoadjuvant therapy (TNT) followed by non-operative management (watch-and-wait) can preserve the rectum without compromising distant relapse-free survival.

Key takeaway:

Patients who achieve a complete response after TNT may safely consider watch-and-wait. The study reported a 95% 30-month distant relapse-free survival, supporting meaningful organ preservation and excellent oncologic outcomes.

This reinforces the importance of accurate response assessment, multidisciplinary decision-making, and emerging tools like circulating tumor DNA in modern rectal cancer care.”

Title: Total neoadjuvant therapy followed by non-operative management or surgery in stage II–III rectal cancer (NO-CUT): a multicentre, single-arm, phase 2 trial

Authors: Alessio Amatu, Giorgio Patelli, Maria Giulia Zampino, Francesca Bergamo, Stefania Mosconi, Federica Tosi, Davide Ciardiello, Sara Lonardi, Giorgia Negrini, Daniela Sibio, Marianna Alessandra Gerardi, Sara Galuppo, Francesco Romeo Filippone, Pietro Carnevali, Simona Borin, Pierluigi Pilati, Elia Poiasina, Erica Bonazzina, Lorenzo Gervaso, Enzo Mammano, Francesco Bracco, Luca Bergamaschi, Gaya Spolverato, Matteo Origi, Uberto Fumagalli Romario, Gianluca Mauri, Nicola Fazio, Edoardo Forti, Giuseppe De Roberto, Chiara Cristofori, Cesare Burti, Luigi Asmundo, Luigi Funicelli, Gaetano Ramondo, Pietro Andrea Bonaffini, Sara Mariano, Luca Lazzari, Silvia Ghezzi, Claudio Isella, Daniela Cantarella, Maria Costanza Aquilano, Luca Bottiglieri, Emanuela Bonoldi, Massimiliano Mutignani, Valter Torri, Enzo Medico, Alberto Bardelli, Silvia Marsoni, Angelo Vanzulli, Mauro Filippo Palazzi, Giovanni Carlo Ferrari, Katia Bencardino, Andrea Sartore-Bianchi, Salvatore Siena

Read the Full Article on The Lancet Oncology

Hassan R. Hashmi: Exciting New Evidence in Rectal Cancer Care

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Alberto Bardelli Alessio Amatu Andrea Sartore Bianchi Angelo Vanzulli cancer Cesare Burti Chiara Cristofori Claudio Isella Daniela Cantarella Daniela Sibio Davide Ciardiello Edoardo Forti Elia Poiasina Emanuela Bonoldi Enzo Mammano Enzo Medico Erica Bonazzina Federica Tosi Francesca Bergamo Francesco Bracco Francesco Romeo Filippone Gaetano Ramondo Gaya Spolverato Gianluca Mauri Giorgia Negrini Giorgio Patelli Giovanni Carlo Ferrari Giuseppe De Roberto Hassan R. Hashmi Katia Bencardino Lorenzo Gervaso Luca Bergamaschi Luca Bottiglieri Luca Lazzari Luigi Asmundo Luigi Funicelli Maria Costanza Aquilano Maria Giulia Zampino Marianna Alessandra Gerardi Massimiliano Mutignani Matteo Origi Mauro Filippo Palazzi Nicola Fazio OncoDaily Oncology Pierluigi Pilati Pietro Andrea Bonaffini Pietro Carnevali rectal cancer Salvatore Siena Sara Galuppo Sara Lonardi Sara Mariano Silvia Ghezzi Silvia Marsoni Simona Borin Stefania Mosconi Uberto Fumagalli Romario Valter Torri