Giuseppe Banna, Consultant Medical Oncologist at Portsmouth Hospitals University NHS Trust, shared a post on LinkedIn:
“Our new international, real-world validation study of the Meet-URO score has just been published in The Oncologist Journal, analysing a large cohort of 1,418 patients with metastatic renal cell carcinoma (mRCC) receiving first-line immunotherapy combinations.
In clinical oncology, we often rely on comparing c-index values to judge the superiority of a prognostic model. Looking strictly at the numbers, the absolute difference between the Meet-URO score and the standard IMDC criteria might seem modest. However, the true clinical value goes far beyond absolute statistical concordance.
The real strength of the Meet-URO score, which integrates IMDC criteria with neutrophil-to-lymphocyte ratio (NLR) and bone metastases, lies in its capacity to refine outcome predictions. Dissecting the heterogeneity within intermediate-risk patients and accurately stratifying extreme prognostic classes, it provides clinicians with a much sharper tool for daily decision-making and patient counselling.
Validating such an accessible tool opens up key perspectives for the future: not only by optimising stratification in upcoming clinical trials, but also by serving as a bridge toward molecular definition and precision oncology in mRCC.
A huge thank you to Sara Elena Rebuzzi, Aruni Ghose, Alessio Signori, and all the international co-authors and centres whose collaborative efforts made this study possible.”
Title: Refining Prognosis in Advanced Renal Cell Carcinoma: International Real-World Validation of the Meet-URO Score in First-Line Immunotherapy Combinations
Authors: Sara Elena Rebuzzi, Aruni Ghose, Sarah Rudman, Balaji Venugopal, Kate Young, Ricky Dylan Frazer, Olubukola Ayodele, Mark Stares, Brent O’Carrigan, Waqas Ali, John McGrane, Ankit Jain, Ondrej Fiala, Vishwani Chauhan, Agnieszka Michael, Anjali Zarkar, Gaurav Kapur, Natalie Charnley, Mehran Afshar, Salil Vengalil, Caroline Forde, Janet Brown, Yüksel Urun, Diletta Bianchini, Amit Bahl, Narayanan Srihari, Fabrizio Di Costanzo, Benjamin Smalley, Joanne Parkes, Simon Crabb, Naveen Vasudev, Alexandr Poprach, Nicholas Brown, Lijo James, Sophia Haywood, Jose Tapia, Anupama Vijay, Jane Parry, Michael Cheung, Ishika Mahajan, Niall O’ Moon, Ritika Abrol, Michaela Tkadlecová, Yamin Shwe Yee Soe, Anum Zargham, Michelle Smith, Sophie Ashley, Orla Hardy, Grisma Patel, Kyaw Kyaw Tun, Emma Johnston, Abdullah Sarwer, Hatice Bölek, Roshani Shrestha, Amarnath Challapalli, James Meegan, Shobana Anpalakhan, Francesco Buono, Eva Kolarikova, David Ka-Wai Leung, Veronica Murianni, Fabio Catalano, Davide Bimbatti, Sebastiano Buti, Alessio Signori, Giuseppe Fornarini, Pasquale Rescigno, Jeremy Yuen Chun Teoh, Giuseppe Luigi Banna
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