Elizabeth McKenna, Executive Editor of Cancer Discovery, shared Cancer Discovery’s post on X, adding:
“It’s another KRAS day at Cancer Discovery!
Three papers now online about mutant KRAS alleles, rewiring that occurs after allele-specific KRAS inhibition, and potential combination approaches – 3/3 by Pietro Scaparone, Alessia Mira, Taek-Chin Cheong, Chiarle lab, AmbrogioLab and colleagues.”
Quoting Cancer Discovery’s post:
“Now online: EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway.”
Title: EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway
Authors: Pietro Scaparone, Alessia Mira, Taek-Chin Cheong, Enrico Patrucco, Biagio Ricciuti, Riccardo Gribaudo, Edoardo Garbo, Rossella Scardaci, Ilenia Savinelli, Sandra Vietti Michelina, Igor Odintsov, Elliott J. Brea, Roberto Mignacco, Rafael B. Blasco, David Santamaría, Claudia Voena, Marco H. Hofmann, Ernest Nadal, Silvia Novello, Mark M. Awad, Roberto Chiarle, Chiara Ambrogio
Other articles featuring Elizabeth McKenna and Cancer Discovery on OncoDaily.
