Corinne Faivre-Finn: Surgery or Radiotherapy for Early-Stage Lung Cancer?
Corinne Faivre-Finn, Professor of Thoracic Radiation Oncology at The University of Manchester, shared a post on LinkedIn about a paper she co-authored with colleagues published in BMJ Open:
“New paper alert.
Delighted to be part of this important study, with the protocol just published in BMJ Open:
‘Surgery or radiotherapy for early-stage cancer study (SORT) target trial protocol: SABR with curative intent versus surgical resection for early-stage NSCLC’
Randomised trials comparing SABR and surgery in early-stage NSCLC have struggled with recruitment, and observational studies are often limited by confounding factors.
The SORT study, led by Richard Grieve, London School of Hygiene and Tropical Medicine, U. of London, uses a target trial emulation approach, leveraging high-quality national datasets to compare outcomes following curative-intent SABR versus surgery in a real-world population
This is a great example of why we need pragmatic studies that reflect everyday clinical practice. With thoughtful design and robust methodology, including instrumental variable analysis to address confounding, such research can generate meaningful evidence to guide patient care.”
Title: Surgery or radiotherapy for early-stage cancer study (SORT) target trial protocol: stereotactic ablative radiotherapy (SABR) with curative intent versus surgical resection for early-stage non-small cell lung cancer (NSCLC)
Authors: Eva Kagenaar, David G. Lugo-Palacios, Andrew Hutchings, Ajay Aggarwal, Stephen O’Neill, Bernard Rachet, John Edwards, Corinne Faivre-Finn, Richard Grieve
You can read the Full Article in BMJ Open.
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