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NCI Center for Cancer Research – cfDNA Offers Non-Invasive Approach to Understand and Treat SCLC without Tumor Biopsies
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Jul 2, 2025, 08:21

NCI Center for Cancer Research – cfDNA Offers Non-Invasive Approach to Understand and Treat SCLC without Tumor Biopsies

NCI Center for Cancer Research posted on LinkedIn:

“Profiling circulating cell-free DNA (cfDNA) has become a fundamental practice in cancer medicine: cfDNA can be obtained through plasma samples. The use of plasma to guide therapy is particularly of interest for use in analyzing small cell lung cancer (SCLC), due to the aggressive nature of this cancer, which makes obtaining tumor biopsies exceedingly challenging.
A study by CCR researchers analyzed cfDNA in plasma samples of 20 patients and found that the cfNDA in the blood matches the genetic information from their tumors, even revealing important changes and resistance mechanisms that the tissue biopsies missed. Their findings suggest that cfDNA can provide a detailed, non-invasive way to understand and treat SCLC without the need for tumor biopsies.
Image: Distributions of single nucleotide variants in cfDNA samples and tumor samples. Of note, the two sample types produced matching information.”

NCI Center for Cancer Research - cfDNA Offers Non-Invasive Approach to Understand and Treat SCLC without Tumor Biopsies

Title: Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor

Authors: Nobuyuki Takahashi, Lorinc Pongor, Shivam P. Agrawal, Mariya Shtumpf, Ankita Gurjar, Vinodh N. Rajapakse, Ahmad Shafiei, Christopher W. Schultz, Sehyun Kim, Diana Roame, Paula Carter, Rasa Vilimas, Samantha Nichols, Parth Desai, William Douglas Figg Sr., Mohammad Bagheri, Vladimir B. Teif, Anish Thomas

Read The Full Article at Genome Medicine.

NCI Center for Cancer Research - cfDNA Offers Non-Invasive Approach to Understand and Treat SCLC without Tumor Biopsies

More posts featuring SCLC.

Ahmad Shafiei Anish Thomas Ankita Gurjar cancer Christopher W. Schultz Diana Roame Lorinc Pongor Mariya Shtumpf Mohammad Bagheri NCI Center for Cancer Research Nobuyuki Takahashi OncoDaily Oncology Parth Desai Paula Carter Rasa Vilimas Samantha Nichols SCLC Sehyun Kim Shivam P. Agrawal small cell lung cancer Vinodh N. Rajapakse Vladimir B. Teif William Douglas Figg Sr.
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