Andrea Casadei Gardini: MAGIC Index for Biliary Tract Cancer – a Step Forward in Personalizing Prognosis
Andrea Casadei Gardini, Associate Professor at Vita-Salute San Raffaele University, shared a post on LinkedIn:
“MAGIC index for BTC: a step forward in personalizing prognosis
We’re excited to share our latest international effort, just published in Liver International: the development and validation of a novel prognostic tool for patients with biliary tract cancer treated with cisplatin, gemcitabine, and durvalumab in the first-line setting — the MAGIC-D index.
Built from a cohort of nearly 400 patients across 11 countries, the MAGIC-D index combines 5 routinely available clinical variables:
Metastatic stage
CEA
Albumin
GGT
NLR ≥3
Patients are stratified into three distinct risk groups (low, intermediate, high), each showing significantly different survival outcomes in both training and validation cohorts:
Low-risk: median OS 18.4 months
Intermediate-risk: median OS 15.9 months
High-risk: median OS 7.8 months
This tool is simple, reproducible, and designed to support real-life clinical decisions, especially when discussing prognosis and planning therapeutic strategies.
Thanks to all the collaborators across Eastern and Western centers who made this work possible!”
Title: A Prognostic Index for Advanced Biliary Tract Cancer Treated With Cisplatin, Gemcitabine and Durvalumab: The MAGIC-D Index
Authors: Mara Persano, Margherita Rimini, Francesca Salani, Federica Lo Prinzi, Federico Nichetti, Anna Saborowski, Lorenzo Antonuzzo, Laura Passeri, Tomoyuki Satake, Frederik Peeters, Caterina Vivaldi, Tiziana Pressiani, Jessica Lucchetti, Jin Won Kim, Oluseyi Abidoye, Salvatore Corallo, Ilario Giovanni Rapposelli, Stefano Tamberi, Fabian Finkelmeier, Guido Giordano, Chiara Pircher, Hong Jae Chon, Chiara Braconi, Aitzaz Qaisar, Chiara Pirrone, Florian Castet, Emiliano Tamburini, Changhoon Yoo, Alessandro Parisi, Anna Diana, Mario Scartozzi, Gerald W. Prager, Antonio Avallone, Marta Schirripa, Il Hwan Kim, Lukas Perkhofer, Ester Oneda, Monica Verrico, Nuno Couto, Jorge Adeva, Stephen L. Chan, Gian Paolo Spinelli, Nicola Personeni, Ingrid Garajova, Maria Grazia Rodriquenz, Silvana Leo, Cecilia Melo Alvim, Ricardo Roque, Giovanni Farinea, Lorenzo Fornaro, Antonio De Rosa, Irene Lanzetta, Rita Balsano, Daniele Lavacchi, Silvia Camera, Masafumi Ikeda, Jeroen Dekervel, Monica Niger, Giulia Tesini, Giuseppe Tonini, Minsu Kang, Tanios Bekaii-Saab, Luca Esposito, Alessandra Boccaccino, Michele Ferrara, Vera Himmelsbach, Matteo Landriscina, Selma Ahcene Djaballah, Gianluca Masi, Arndt Vogel, Sara Lonardi, Lorenza Rimassa, Andrea Casadei-Gardini
You can read the Full Article on Liver International
More posts featuring Biliary Tract Cancer
-
Challenging the Status Quo in Colorectal Cancer 2024
December 6-8, 2024
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023