Armando Orlandi: Prophylactic Surgeries Improve Survival in Young BRCA Carriers
Armando Orlandi, Medical Director at the Agostino Gemelli University Hospital Foundation IRCCS, posted on LinkedIn:
“GROUNDBREAKING STUDY: Prophylactic Surgeries Improve Survival in Young BRCA Carriers.
For the first time, a landmark international study published in The Lancet Oncology provides compelling evidence that risk-reducing mastectomy (RRM) significantly improves survival outcomes in BRCA carriers under 40 with previous breast cancer
Key Primary Findings:
• Global cohort of 5,290 young BRCA carriers across 109 centers.
• RRM associated with 35% reduction in mortality risk.
• Benefits observed regardless of specific BRCA gene, tumor subtype, or age.
Additional Objectives Achieved:
• Risk-reducing salpingo-oophorectomy (RRSO) also significantly improved overall survival (42% reduction in mortality).
• RRSO showed particularly strong benefit in BRCA1 carriers (56% reduction).
• Both procedures reduced incidence of second primary cancers by more than half.
• Significant improvements in disease-free survival and breast cancer-free interval.
• Identified benefits regardless of timing of BRCA testing (before or after diagnosis).
• Provided evidence for optimal surgical approaches in different patient subgroups.
The Lancet Oncology
Until now, evidence was lacking for this unique high-risk population. These findings provide critical guidance for oncologists and surgeons counseling young BRCA carriers on cancer risk management strategies, particularly balancing primary cancer relapse risk against second malignancy risk.
Exceptional Leadership:
Congratulations to Dr. Eva Blondeaux and Prof. Matteo Lambertini for their remarkable achievement in orchestrating this massive international collaboration. Their extraordinary networking and organizational capabilities made it possible to coordinate 109 centers across five continents—truly showcasing the power of global scientific cooperation to advance patient care.
This comprehensive research represents a major advancement in personalized medicine for young women with hereditary breast cancer, offering clearer evidence-based guidelines for surgical interventions that can significantly extend lives.”
Title: Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study.
Authors: Eva Blondeaux, Amir Sonnenblick, Elisa Agostinetto, Raphaëlle Bas, Hee J Kim, Maria A Franzoi, Rinat Bernstein-Molho, Sabine Linn, Ava Kwong, Katarzyna Pogoda, Judith Balmana, Ann Smeets, Jyoti Bajpai, Halle C F Moore, Ann H Partridge, Kelly-Anne Phillips, Angela Toss, Christine Rousset-Jablonski, Fedro A Peccatori, Tiphaine Renaud, Alberta Ferrari, Shani Paluch-Shimon, Pablo Mando, Jeong E Lee, Robert Fruscio, Wanda Cui, Stephanie M Wong, Claudio Vernieri, Kathryn J Ruddy, Maria V Dieci, Alexios Matikas, Mariya Rozenblit, Deniz C Guven, Minna Lee, Cynthia Villarreal-Garza, Shelley E Hwang, Laura De Marchis, Fabio Puglisi, Zoe Kemp, Pedro A Meireles, Anastasia Parokonnaya, Gustavo Werutsky, Maiko Okano, Hatem A Azim Jr, Kleida Mati, Shoshana Rosenberg, Richard Gelber, Luca Boni, Matteo Lambertini
Read The Full Article at The Lancet Oncology.
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