Deepak Gupta: Sarcoma patient referred for palliative RT for pain in view of metastatic disease
Deepak Gupta, Associate Director at Medanta Hospital, shared on LinkedIn:
“Sarcoma patient referred for palliative RT for pain in view of metastatic disease. Treated with Lattice first fraction lattice with high doses for vertices with low dose area of valleys followed by CFRT. Biopsy was also done post treatment shows necrosis only. PETCECT Post 3 month CMR.
It can be a way forward for treating sarcomas and other sites but still long way to go
3D GRID radiation is also commonly referred to as Lattice Radiotherapy (LRT).
What it is:
Lattice Radiotherapy is an advanced form of spatially fractionated radiotherapy (@SFRT), where high doses of radiation are delivered to specific small volumes (vertices) within a large tumor using a 3D grid-like pattern, while the surrounding tumor tissue receives a lower dose. The goal is to stimulate a bystander effect and immune response while minimizing damage to surrounding normal tissue.
Key Points:
- It’s a modern evolution of 2D GRID therapy.
- It uses 3D conformal radiation, often with IMRT or VMAT techniques.
- High-dose “nodes” or “vertices” are placed inside the tumor in a lattice or grid pattern.
- Commonly used in large or radioresistant tumors.”
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