Eric Singhi/X
Feb 22, 2025, 05:15
Eric K. Singhi: Not all EGFR mutations are the same
Eric K. Singhi, Assistant Professor in the Department of General Oncology at The University of Texas MD Anderson Cancer Center, posted on X:
“Not all EGFR mutations are the same. Dr. Xiuning Le takes us through treatment options for EGFR PACC mutations.
- PACC mutations ~12% of EGFR mutations, often as compound mutations.
- Current SOC is heterogenous.
- Novel TKIs under development.”
Xiuning Le, Deputy Section Chief of Thoracic Medical Oncology at MD Anderson Cancer Center, shared this post on X, adding:
“EGFR PACC mutations is one of the fastest moving space in TKI development in lung cancer, together with EGFR ex20 and HER2 ex20. Multiple global phase 3 trials aim to move highly effective TKIs to the first-line setting to render maximal benefit to our patients.”
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