December, 2024
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Long-term follow-up of the COMMAND presented by Gullermo Garcia-Manero at ASH24
Dec 10, 2024, 19:04

Long-term follow-up of the COMMAND presented by Gullermo Garcia-Manero at ASH24

Mohamad Mohty, Professor of Hematology at Sorbonne University and head of the Clinical Hematology and Cellular Therapy Department at Saint-Antoine Hospital, reshared a post on X by Uriel Suárez, Resident of hematology at Jiménez Díaz Foundation University Hospital, adding:

“COMMAND is the largest randomized trial in MDS, and now we have long-term follow-up presented by Gullermo Garcia-Manero at ASH24 EPO/ESA clearly needs to retire very quickly.

Luspatercept works in ALL subgroups irrespective of the ring sideroblasts status. The field is finally entering into a modern era.

Luspa is an incredible example on the transfer of scientific discoveries to the bedside (it is a recombinant fusion protein that binds TGF β superfamily ligands to reduce SMAD2 and SMAD3 signaling).”

Quoting Uriel Suárez’s post:

“ASH24. Long-term response analysis of transfusion independence in ESA–naive patients with very low-, low-, or intermediate-risk MDS treated with Luspatercept Vs Epoetin Alfa in the COMMANDS Trial.”

More posts featuring Mohamad Mohty.