Nicholas Navin, Director, Advanced Spatial Genomics Core, Professor and Chair, Department of Systems Biology, Director, CPRIT Single Cell Genomics Center, Associate Professor at UT MD Anderson shared on LinkedIn:
“A major study from our lab at UT MD Anderson on DCIS breast cancer was published today in Science Magazine titled ‘ A cellular atlas of the preinvasive breast cancer microenvironment’.
This work was led by Aatish Thennavan and Siyuan. He from our group and a wonderful collaboration with Savitri Krishnamurthy (Pathology) and Alastair Thompson, BSc (Hons), at Baylor. We analyzed over 854,911 cells from 159 patients representing different stages of the disease progression from normal to DCIS to ER+ invasive breast cancer.
Our data shows remodeling of fibroblasts, vascular and basal cells that encircle the DCIS regions and immunosuppressive ducts that support the growth of the preinvasive cancer cells.
Congrats to the whole team on this important project that improves our fundamental understanding of DCIS!”
Title: A cellular atlas of the preinvasive breast cancer microenvironment
Authors: Siyuan He, Aatish Thennavan, Runmin Wei, Shanshan Bai, Jianzhuo Li, Chante Bethell, Emi Sei, Mitchell Rao, Tapsi Kumar, Chenling Tang, Ivan Marin, Jessica Montalvan, Chandandeep Nagi, Bora Lim, Savitri Krishnamurthy, Alastair Thompson, Nicholas Navin.
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