Zihai Li: Are NK Cells Friends or Foes In Cancer Immunotherapy?
Zihai Li, Professor and Founding Director at the Pelotonia Institute for Immuno-Oncology, shared a post on X:
“Are NK cells friends or foes in cancer immunotherapy?
We found they impede the development of anti-tumor NK-regulated T cells (NKRTs).
A separate study by MarineLab showed that NK cells contribute to ICB resistance in melanoma. “
Title: Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype
Journal: Cancer Discovery
Authors: Joanna Pozniak, Niccolò Roda, Ewout Landeloos, Asier Antoranz, Yannick Van Herck, Amber De Visscher, Philip Georg Demaerel, Lukas Vanwynsberghe, Jeroen Declercq, Christos Gkemisis, Greet Bervoets, No-Joon Song, Ayse Bassez, Robin Browaeys, Lotte Pollaris, Francesca M. Bosisio, Veerle Boecxstaens, Yvan Saeys, Diether Lambrechts, Zihai Li, Patrick Matthys, Oliver Bechter, Jean-Christophe Marine
Also read OncoDaily’s special “Melanoma (Skin Cancer): Symptoms, Causes, Stages, Diagnosis and Treatment“.
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