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Nico Gagelmann: Closing the Gap – PTCy Boosts Survival After Mismatched Stem Cell Transplants
Jun 18, 2025, 15:13

Nico Gagelmann: Closing the Gap – PTCy Boosts Survival After Mismatched Stem Cell Transplants

Nico Gagelmann, Young National Society Ambassador at European Hematology Association (EHA) and Chair of the CAR-T for plasma cell disorder committee at The EBMT, shared a post on X:

“Out now in Journal of Clinical Oncology.
Closing the Gap: PTCy Boosts Survival After Mismatched Stem Cell Transplants
Summary:
In a multicenter phase II trial, post-transplant cyclophosphamide (PTCy)-based GVHD prophylaxis enabled strong 1-year survival outcomes in patients receiving peripheral blood stem cell transplants from HLA-mismatched unrelated donors (MMUDs).
Among 145 patients – 59% from underrepresented groups – 1-year overall survival reached 83.8% (MAC) and 78.6% (RIC/NMA), with low rates of severe GVHD.
Outcomes were comparable regardless of the degree of mismatch. These findings suggest PTCy regimens can safely expand donor access across all ethnic backgrounds.”

Nico Gagelmann

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