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Gene Expression Profiling of Breast Cancer Brain Metastases – Mirrors of Medicine
Photo: Depositphotos
Jul 28, 2025, 14:58

Gene Expression Profiling of Breast Cancer Brain Metastases – Mirrors of Medicine

Mirrors of Medicine shared a post on X, about a recent article by G. Griguolo et al published in ESMO Open:

“Gene expression profiling in a retrospective real-world cohort of breast cancer brain metastases and paired primary tumors identifies biological changes with potential therapeutic implications

This study investigated the genomic landscape of breast cancer brain metastases (BCBMs) by comparing them with matched primary breast tumors to better understand the biological evolution during metastasization.

Analysis revealed a high prevalence of non-luminal subtypes in BCBMs, particularly HER2-enriched and basal-like profiles, even among tumors originally classified as luminal or hormone receptor-positive/HER2-negative.

A notable shift toward the HER2-enriched subtype was observed in brain metastases, accompanied by recurrent changes in gene expression, including alterations in genes related to cell survival, migration, HER2 signaling, and endocrine response.”

Title: Gene expression profiling in a retrospective real-world cohort of breast cancer brain metastases and paired primary tumors identifies biological changes with potential therapeutic implications

Authors: G. Griguolo, M.V. Dieci, S. Fineberg, C. Pinato, M. Bottosso, L. Bauchet, F. Miglietta, J. Jacob, V. Rigau, M.C. Guarascio, F. Zanconato, F. Schiavi, M. Fassan, A.P. Dei Tos, W. Jacot, S. Piccolo, A. Darlix, V. Guarneri

Read the Full Article on ESMO Open

Gene Expression Profiling of Breast Cancer Brain Metastases - Mirrors of Medicine

More posts featuring Breast Cancer.

A. Darlix A.P. Dei Tos Breast Cancer C. Pinato cancer ESMO Open F. Miglietta F. Schiavi F. Zanconato G. Griguolo J. Jacob L. Bauchet M. Bottosso M. Fassan M.C. Guarascio M.V. Dieci Mirrors of Medicine OncoDaily Oncology S. Fineberg S. Piccolo V. Guarneri V. Rigau W. Jacot
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