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Safety of Lorlatinib in ALK positive NSCLC

Lung Cancer

Nov 25, 2024, 17:53

Safety of Lorlatinib in ALK positive NSCLC

Biagio Ricciuti, Thoracic Medical Oncologist at Dana-Farber and Harvard Medical School, shared a recent article by Sai-Hong Ignatius Ou on X:

“Final OS and long-term safety of lorlatinib in ALK positive Non-Small Cell Lung Cancer from the pivotal phase 2 study at JTO and The International Association for the Study of Lung Cancer.

Median OS not reached in Experiment-1 (treatment naive) and Experiment-3A (prior crizotinib ± CT)
37.4 months in Experiment-3B (prior 2nd gen ALK TKI ± CT)
19.2 months in Experiment-4-5 (>2 ALK TKI ± CT)
Permanent discontinuation rate due to AEs 13%”

Title: Brief Report: Final overall survival and long-term safety of lorlatinib in patients with ALK-positive non-small cell lung cancer from the pivotal phase 2 study

Authors: Sai-Hong Ignatius Ou, Benjamin J. Solomon, Benjamin Besse, Alessandra Bearz, Chia-Chi Lin, Rita Chiari, D. Ross Camidge, Jessica J. Lin, Antonello Abbattista, Francesca Toffalorio and Ross A. Soo

Safety of Lorlatinib

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