Radiation Oncology Institute RFP: Optimizing Combination Radiation Therapy and Immunotherapy

Radiation Oncology Institute RFP: Optimizing Combination Radiation Therapy and Immunotherapy

Due Date: 11/17/2025

Annual ROI (the ASTRO Foundation) request for proposals to catalyze high-priority research on how to effectively combine radiation therapy and immunotherapy to improve patient outcomes, generate tangible deliverables (e.g., decision tools, educational materials, abstracts/manuscripts), and position projects for follow-on funding. 

Eligibility Criteria:

  • Qualified individuals from institutions/organizations in the radiation oncology community; pre-doctoral students are not eligible.

  • Residents and postdoctoral fellows require a faculty mentor.

  • The institution managing funds must be a qualified 501(c)(3) or U.S. government-sponsored university, or the Canadian equivalent; others should contact ROI to identify a qualifying institution before LOI submission. 

Funding Details:

  • Typical budget: up to USD 50,000 total over 2 years; larger budgets considered up to a firm cap of USD 100,000.

  • No indirect/overhead costs permitted.

  • Projects may run up to 2 years; second-year funding is contingent on an approved interim report.

  • Projects must start August 1, 2026 and end no later than July 31, 2028.

  • Priority for efficient, high-impact proposals aligned with ROI’s mission and producing practical outputs for the field. 

Deadline:

  • Letter of Intent (required): November 17, 2025, 5:00 p.m. ET.

  • Full proposal invitations: December 2025.

  • Full proposal (by invitation): February 17, 2026, 5:00 p.m. ET.

  • Notification of awards: April 2026.

  • Award start date: August 1, 2026. 

Where to go for further information:

  • Application portal: ProposalCentral → “Grant Opportunities” → filter by “ASTRO and ROI”; complete required LOI and, if invited, full proposal components (abstracts, relevance statement, 4-page project description, budget/justification, biosketches, letters of support, and required e-signatures).