Aug 14, 2025, 08:01

ALSF Crazy 8 Initiative – Pediatric Brain Tumor Grant

Large-scale, multi-institution awards to develop more effective, less toxic treatments for pediatric/adolescent brain and spinal cord tumors; emphasizes innovative science, team collaboration, and real-world impact.

Eligibility Criteria:

PI, Co-PIs, Co-Is hold MD/PhD (or equivalent) and faculty appointment; strong record of productivity.
Global, nonprofit host institutions; funds paid in USD.
New teams only: PIs/Co-PIs may not have led a previously funded Crazy 8 project; Co-Is cannot be on a currently funded Crazy 8 team (admin exceptions by request).
Consortium of ≥2 institutions with complementary expertise; patient advocate strongly encouraged.

Funding Details:

Budget range: USD 3–5 million total over 4 years; cost efficiency considered.
Indirect costs up to 10% of total direct costs (may be applied to subawards’ direct costs).
NIH salary cap applies; no renewals (one no-cost extension possible).
Allowable: fringe, supplies, small equipment, travel (include annual Crazy 8 Summit).
Resource/data sharing plan required.

Deadline:

LOI due: November 5, 2025.
Full proposals (by invitation): April 28, 2026.
Finalist virtual presentations: September 2026.
Award notification: November 2026.

Where to Go for Further Information:

Apply via ProposalCentral (ORCID required).
Program contact: [email protected]; general: [email protected].

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