How ovarian cancer hampers immune cells by cutting off their energy supply? – Cancer Research Institute
Cancer Research Institute shared on LinkedIn:
“A groundbreaking study from CRI affiliated scientists, including CRI-Thompson Family Foundation CLIP Investigator Dr. Juan R. Cubillos-Ruiz, CRI-Sandra Schnitzer Fellow Dr. Camilla Salvagno, and former Dr. Keith Landesman Memorial Fellow Dr. Chang-Suk Chae of Weill Cornell Medicine, former CRI CLIP Investigator Dr. Jose Ramon Conejo-Garcia of Duke University School of Medicine, and CRI Clinical Accelerator Investigator Dr. Dmitry Zamarin of Icahn School of Medicine at Mount Sinai, demonstrates how ovarian cancer cleverly hampers immune cells by cutting off their energy supply.
Ovarian cancer manipulates the TAGLN2 protein, which helps fatty acid binding protein 5 (FABP5) transport essential fatty acids needed for T cell energy and effective anti-tumor responses. Researchers observed how ovarian tumor-induced stress reduces TAGLN2 levels, leaving T cells starved for fatty acids and less effective at fighting cancer.
Restoring TAGLN2 not only revives T cell energy, but also boosts the effectiveness of CAR T cell therapy in preclinical models. Continue to explore how this discovery paves the way for innovative strategies to enhance immunotherapy for ovarian cancer patients.”
Transgelin 2 guards T cell lipid metabolism and antitumour function
Authors: Sung-Min Hwang, Deepika Awasthi, Jieun Jeong, Tito A. Sandoval, Chang-Suk Chae, Yusibeska Ramos, Chen Tan, Matías Marin Falco, Camilla Salvagno, Alexander Emmanuelli, Ian T. McBain, Bikash Mishra, Lionel B. Ivashkiv, Dmitriy Zamarin, Evelyn Cantillo,Eloise Chapman-Davis, Kevin Holcomb, Diana K. Morales, Xiaoqing Yu, Paulo C. Rodriguez, Jose R. Conejo-Garcia, Martin Kaczocha, Anna Vähärautio, Minkyung Song, Juan R. Cubillos-Ruiz
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