Zhaohui Su, VP of Biostatistics at Ontada, shared a post on LinkedIn:
“This is one of the best articles on target trial emulation (TTE). Adrien Laurent explains how TTE makes real‑world evidence (TWE) more reliable by designing observational studies to mimic randomized clinical trials (RCT).
By defining eligibility, treatments, time zero, outcomes, and follow‑up as in a hypothetical trial, and adjusting for confounding, researchers can reduce bias and draw more credible causal conclusions.
Examples across oncology, diabetes, and neurology show that this method often aligns with RCT results and is increasingly encouraged by regulators.”
Title: Target Trial Emulation: A Framework for Causal RWE
Authors: Adrien Laurent
Read the Full Article.
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