Weill Cornell University shared a post on LinkedIn about a recent article by Mikhail Roshal et al, published in Blood Cancer Journal:
“Weill Cornell Medicine researchers have demonstrated, for the first time, that Hodgkin lymphoma cancer cells from patient samples are immune cells stuck in an ‘identity crisis.’
Normally, a B cell matures into a plasma cell that produces antibodies to fight infection, but in this case, the cells are trapped partway through the transition. They switch off key B cell features but never fully mature into functional plasma cells, instead surviving as malignant Hodgkin lymphoma cells, also called Reed-Sternberg cells.
The findings, published April 22 in Blood Cancer Journal, reframe Hodgkin lymphoma as a cancer of failed cell development, rather than simply uncontrolled growth, and suggest new diagnostic biomarkers to distinguish it from other related non-Hodgkin lymphomas.”
Title: Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Sternberg cells reveals escape from NK cell recognition and an unfolded protein response
Authors: Mikhail Roshal, Isabella Y. Kong, Wikum Dinalankara, Jonathan B. Reichel, Matthew Teater, Bhavneet Binder, Sakellarios Zairis, Joshua D. Brody, Sunita I. Park, Alexandra E. Kovach, Nitya Gulati, Matthew J. Oberley, Megan S. Lim, Matthew J. Barth, Olivier Elemento, Ari Melnick, Raul Rabadan, Amy Chadburn, Luigi Marchionni, Lisa Giulino-Roth, Ethel Cesarman
Read the Full Article on Blood Cancer Journal
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