Wafik El-Deiry, Director of the Legorreta Cancer Center at Brown University and Chair of the WIN Consortium in Cancer Personalized Medicine, shared some top articles.
1. Title: Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53
Authors: Binyan Xu, Xufeng Hou, Maoyuan Wang, Lin Qiu, Xiling Chen, Guoming Deng, Daixuan Zhou, Yun Feng, Jinzhao Han, Xiaojing Meng, Hongying Fan, Weisen Zeng, Yang Bai
2. Title: KRAS-targeted therapies in cancer: novel approaches and overcoming resistance
Authors: Daolin Tang, Guido Kroemer, Rui Kang
3. Title: Metastatic Recurrence Among Adolescents and Young Adults With Cancer
Authors: Ann Brunson, Ted Wun, Renata Abrahão, Charles P. Quesenberry, Jessica Chubak, Kathryn J. Ruddy, Chun R. Chao, Erin E. Hahn, Candice A. M. Sauder, Hazel B. Nichols, Lawrence H. Kushi, Theresa H. M. Keegan
4. Title: p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1–driven ovarian cancers
Authors: Chance C. Sine, Lotte P. Watts, Brianna Fernandez, Nasreen Marikar, Jianxin Wang, Erik S. Knudsen, Agnieszka K. Witkiewicz, Sabrina L. Spencer
5. Title: A triple-action PROTAC for wild-type p53 cancer therapy
Authors: Gregory H. Bird, Utsarga Adhikary, Michael J. Schmidt, Marina Godes, Bethany Tesar, Christina M. Camara, Joao A. Paulo, Julia F. Vidlak, Thomas M. DeAngelo, Marilyn Marquez, Prafulla Gokhale, Ruitong Li, Shannan J. Ho Sui, Michael D. Cameron, Steven P. Gygi, Loren D. Walensky
6. Title: Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges
Authors: Khalil Choucair, Hafsa Imtiaz, Md Hafiz Uddin, Misako Nagasaka, Mohammad Najeeb Al-Hallak, Philip A. Philip, Bassel El-Rayes, Boris C. Pasche, Asfar S. Azmi
7. Title: Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival
Authors: Margarita Dzama-Karels, Mallory Sokolowski, Peyton Kuhlers, Jacqueline A. Brinkman, John P. Morris IV, Jesse R. Raab
8. Title: NSD2 targeting reverses plasticity and drug resistance in prostate cancer
Authors: Jia J. Li, Alessandro Vasciaveo, Dimitris Karagiannis, Zhen Sun, Kristjan H. Gretarsson, Xiao Chen, Ouathek Ouerfelli, Fabio Socciarelli, Ziv Frankenstein, Hanyang Dong, Min Zou, Wei Yuan, Guangli Yang, Gabriel M. Aizenman, Tania Pannellini, Xinjing Xu, Himisha Beltran, Yu Chen, Kevin Gardner, Brian D. Robinson, Johann de Bono, Or Gozani, Cory Abate-Shen, Mark A. Rubin, Massimo Loda, Charles L. Sawyers, Andrea Califano, Chao Lu, Michael M. Shen
9. Title: MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance
Authors: Mark White, Megan L. Mills, Laura M. Millett, Kathryn Gilroy, Yourae Hong, Lucas B. Zeiger, Rosalin J. Simpson, Shania M. Corry, Amelia Ligeza, Tamsin R. M. Lannagan, Susanti Susanti, Rachel A. Ridgway, Ayse S. Yazgili, Lucile Grzesiak, Raheleh Amirkhah, Catriona A. Ford, Nikola Vlahov, Hannah Tovell, Leah Officer-Jones, Catherine Ficken, Rachel Pennie, Arafath K. Najumudeen, Alexander Raven, Nadia Nasreddin, Ekansh Chauhan, Andrew S. Papanastasiou, Colin Nixon, Vivienne Morrison, Rene Jackstadt, Janet S. Graham, Crispin J. Miller, Sarah J. Ross, Simon T. Barry, Valeria Pavet, Richard H. Wilson, John Le Quesne, Philip D. Dunne, Sabine Tejpar, Simon Leedham, Andrew D. Campbell, Owen J. Sansom
10. Title: Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens
Authors: Raymond W. Zhou, Paresh Kumar Purohit, Jai Hyun Kim, Sung-Uk Lee, Nicole Burshteyn, Delia Tifrea, Andres Cordon, Ani Grigorian, Barbara L. Newton, Robert A. Edwards, Michael Demetriou
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