Top 5 Articles of the Week Suggested by Vivek Subbiah

Vivek Subbiah, Chief of Early-Phase Drug Development at the Sarah Cannon Research Institute, shared some top articles.

1. “Hot off the press in ASCO, JCO Oncology Advances.

Pleased to share our study ‘Impact of FDA Project Optimus Guidance on Design of Early-Phase Clinical Trials’

• Analysis of 367 phase I oncology trials (2021-2024) reveals Project Optimus is transforming cancer drug development:
• Bayesian designs surged 48% → 75%
• 30% now include dose-optimization plans

Moving beyond max tolerated dose approach

This shift toward smarter, more patient-centered trial design marks a pivotal moment in early-phase cancer research”

Title: Impact of Food and Drug Administration Project Optimus Guidance on Design of Early-Phase Clinical Trials

Journal: JCO

Authors: Deepak Bhamidipati, Suzanne Jones, David Spigel, Gerald Falchook, Manish Patel, Howard Burris, and Vivek Subbiah

Read the full article.

2. Title: EML4-ALK variant-specific genetic interactions shape lung tumorigenesis

Journal: Cancer Discovery

Authors: Alberto Diaz-Jimenez, Emily G. Shuldiner, Kalman Somogyi, Karen Shih, Oscar Gonzalez-Velasco, Mulham Najajreh, Stewart Kim, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Benedikt Brors, Ilse Hofmann, Smruthy Sivakumar, Saumya D. Sisoudiya, Ethan S. Sokol, Hongchen Cai, Dmitri A. Petrov, Monte M. Winslow, and Rocio Sotillo

Read the full article.

3. Title: The molecular and functional landscape of resistance to FOLFIRI chemotherapy in metastatic colorectal cancer

Journal: Cancer Discovery

Authors: Marco Avolio, Simonetta M. Leto, Francesco Sassi, Barbara Lupo, Elena Grassi, Irene Catalano, Eugenia R. Zanella, Valentina Vurchio, Francesca Cottino, Petros K. Tsantoulis, Luca Lazzari, Paolo Luraghi, Martina Ferri, Francesco Galimi, Enrico Berrino, Sara E. Bellomo, Marco Viviani, Alberto Sogari, Gianluca Mauri, Federica Tosi, Federica Cruciani, Andrea Sartore-Bianchi, Salvatore Siena, Felice Borghi, Valter Torri, Elena Élez, Josep Tabernero, Maria Nieva, Clara Montagut, Noelia Tarazona, Andres Cervantes, Sabine Tejpar, Alberto Bardelli, Caterina Marchiò, Silvia Marsoni, Andrea Bertotti, and Livio Trusolino

Read the full article.

4. Title: Translating Artificial Intelligence Breakthroughs into Cancer Diagnostic Breakthroughs

Journal: Cancer Discovery

Authors: Juan M. Lavista Ferres, Elliot K. Fishman, Ed Catmull, Bert Vogelstein, and Joshua T. Vogelstein

Read the full article.

5. Title: When AI rejects your grant proposal: algorithms are helping to make funding decisions

Journal: Nature

Authors: David Adam

Read the full article.

More from Vivek Subbiah on OncoDaily.