Stephen V Liu, Director of Thoracic Oncology, Chief of the Division of Hematology and Oncology, and Associate Professor at Georgetown Lombardi Comprehensive Cancer Center, shared a post on shared a post on X:
“Lungscape Cohort used panTRK IHC in 1703 resected NSCLC: 69 IHC+ cases and only 1 confirmed fusion (false positive rate of 4%). NGS cohort found 11 fusions in 24243 pts (incidence 0.03%) and 5 were retested with IHC – only 1 weakly positive.”
Title: Prevalence and characteristics of NTRK fusions in 25,946 patients with non-small cell lung cancer
Authors: Teodora Radonic, Sepehr Rahmani-Khajouei, Urania Dafni, Albrecht Stenzinger, Martina Haberecker, Line Bille Madsen, Kim Monkhorst, Jacek Kowalski, Javier Hernandez-Losa, Keith M. Kerr, Ernst Jan M. Speel, Lukas Bubendorf, Leena Joseph, Atilio Navarro, Erik Thunnissen, Irene Sansano, Lisa M. Hillen, Wojciech Biernat, Miriam Christoffel, Lydia Tsamtsouri, Roswitha Kammler, Solange Peters, Martin Zoche, Rolf A. Stahel, Stephen P. Finn
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